Featured Test

BRAC Mutation Panel

TESTING OPTION FOR BREAST, OVARIAN, PROSTATE, PANCREATIC CANCERS

BRCA Panel analysis can be performed on a patient who has a family history or is suspected of having breast, ovarian, prostate, or pancreatic cancer or for determining a genetic mutation for a patient with a clinical diagnosis of one of these cancers. Germline mutations in the BRCA1 and/or BRCA2 genes are associated with an increased risk for these cancers.

Featured Test

Factor V Leiden

MUTATION DETECTION FOR THROMBOPHILIA FOR BLOOD CLOTS DEVELOPMENT

Factor V Leiden thrombophilia is caused by a specific mutation in the F5 or Factor V gene. Most people with factor V Leiden thrombophilia have one "normal" F5 gene and one with the factor V Leiden gene mutation. Still, it is estimated that 95% of people with factor V Leiden never develop a clot.

Featured Test

Hereditary Breast and Ovarian Cancer (HBOC) Panel

Hereditary breast and ovarian cancer (HBOC) syndrome is an inherited cancer-predisposition syndrome that tends to affect both men and women (breast cancer) and woman (ovarian cancer) earlier in life, usually before the age of 50. Gene list: ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, STK11, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, PTEN, RAD51C, RAD51D, TP53, FANCC, XRCC2.

Featured Test

Hereditary Hemochromatosis Mutation

Mutation detection in candidate gene for hereditary hemochromatosis. Hereditary hemochromatosis is a disorder that causes the body to absorb excess iron, leading to overload and eventually damage tissues and organs. HFE gene has two common mutations, C282Y and H63D both of which are tested using PCR.

Featured Test

Colorectal Cancer Germline NGS Panel

TESTING FOR HEREDITARY NONPOLYPOSIS COLORECTAL CANCER (LYNCH SYNDROME)

Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is a genetic condition that is associated with a high risk of colon cancer and many other common cancers (stomach, small intestine, ovary, upper urinary tract, brain, etc.) Use for the detection of germline pathogenic variants in patients at increased risk for colon cancer. Gene list: APC, ATM, AXIN2, BMPR1A, CDH1, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53

READ MO RE

Comprehensive Testing Solutions

Disease-specific TEST MENU

AUTISM SPECTRUM DISORDERS/ INTELLECTUAL DISABILITY

Chromosomal Microarray Analysis
Fragile X Syndrome Mutation
CDKL5 Gene Sequencing
GDI1 Gene Sequencing
MBD5 Gene Sequencing
MEF2C Gene Sequencing
NLGN3 Gene Sequencing
NLGN4X Gene Sequencing
SHANK2 Gene Sequencing
SHANK3 Gene Sequencing
SLC9A6 Gene Sequencing
TCF4 Gene Sequencing
UBE3A Gene Sequencing

MECP2 (RETT SYNDROME)

MECP2 Gene Sequencing
MECP2 Deletion/Duplication
MECP2 Targeted Sequencing Familial

PTEN HARMARTOMA TUMOR SYNDROME

PTEN Gene Sequencing
PTEN Deletion/Duplication
PTEN Targeted Sequencing Familial

BREAST AND OVARIAN CANCER

BRCA1 and BRCA2 Gene Sequencing
BRCA1 and BRCA2 Targeted Sequencing, Familial
BRCA1 and BRCA2 Deletion/Duplication
BRCA Ashkenazi Jewish Founder Mutations
BRCA Mutation Panel
Hereditary Breast and Ovarian Cancer (HBOC)
Comprehensive Germline NGS Panel
Hereditary Breast and Ovarian Cancer (HBOC)
High-Moderate Risk Germline NGS Panel
PTEN Gene Sequencing
PTEN Deletion/Duplication
TP53 Gene Sequencing
TP53 Deletion/Duplication

COLORECTAL CANCER

Colorectal Cancer Germline NGS Panel
MSH2 Gene Sequencing

CYSTIC FIBROSIS

Cystic Fibrosis Full Gene Sequencing
Cystic Fibrosis Deletion/Duplication
Cystic Fibrosis Diagnostic Mutation Detection
Cystic Fibrosis Targeted Sequencing Familial

HEARING LOSS

GJB2 (Connexin 26) Mutation Analysis
GJB2 (Connexin 26) Targeted Sequencing Familial
GJB6 (Connexin 30) Deletion Analysis
WFS1 (Wolfram Syndrome) Gene Sequencing

NOONAN SYNDROME

PTPN11 Gene Sequencing
KRAS Gene Sequencing
SOS1 Gene Sequencing

FRAGILE X SYNDROME

Fragile X Syndrome Mutation Detection

LI-FRAUMENI SYNDROME

TP53 Gene Sequencing
TP53 Deletion/Duplication

NEUROFIBROMATOSIS

NF1 Gene Sequencing

MISCELLANEOUS

Apolipoprotein E Genotyping
Factor V Leiden Mutation
Hereditary Hemochromatosis Mutation
Prothrombin 20210 Mutation

CANCER GERMLINE NGS PANELS (64 GENES)

Colorectal Cancer Germline NGS Panel
19 Genes: MLH1, MSH2, MSH6, MUTYH, PMS2, EPCAM, APC, TP53, PTEN, STK11, SMAD4, BMPR1A, CDH1, CHEK2, GREM1, POLD1, POLE, ATM, AXIN2

Hereditary Breast and Ovarian Cancer Comprehensive Germline NGS Panel
21 Genes: ATM, BARD1, BRAC1, BRAC2, BRIP1, CDH1, STK11, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, PTEN, RAD51C, RAD51D, TP53, FANCC, XRCC2

Hereditary Breast and Ovarian Cancer High-Moderate Risk Germline NGS Panel
9 Genes: ATM, BRAC1, BRAC2, BRIP1, CDH1, CHEK2, PALB2, PTEN, TP53

GET STARTED

Order a test today.

ORDER NOW

MEET DR. TAYEH

EXPERTISE DELIVERED PERSONALLY

Our quality commitment extends to how we communicate the results of our analyses. Our reports are developed with the right language and terminology to clarify complex data. I am available to answer questions and help providers prepare to discuss findings with patients and families. When more help is needed, clients can also connect with an MLabs board-certified genetic counselor.

Marwan Tayeh, Ph.D.
Associate Professor of Pediatric Genetics.
Director, Molecular Genetics

SEE ALL EXPERTS

PERSONALIZED TESTING

YOUR FIRST STEP TO CANCER DIAGNOSIS

MLabs offers state-of-the-science blood testing for inherited (germline) mutations impacting both adult and pediatric patients. These molecular signatures are used to make the most precise diagnosis possible, guiding patient-specific plans for prevention, treatment and monitoring.

Analytical platforms include Sanger DNA sequencing for an extensive list of genes, SNP chromosomal microarrays, relative-quantitative PCR, methylation analysis, MLPA, mutation screening panels (xTAG, Luminex) and SNP testing.

Next-generation sequencing (NGS) modalities make it possible identify multiple genetic mutations with excellent sensitivity and broad coverage with one test, while preserving the integrity of a specimen.

NGS multi-gene germline panels are available for the following cancer types:

Breast and Ovarian Cancer
Colorectal Cancer
Endometrial/Uterine Cancer
Melanoma Cancer
Neurofibromatosis
Pancreatic Cancer

Paraganglioma Cancer
Prostate Cancer
Renal Cancer
Stomach Cancer

MOLECULAR AT ITS BEST

CUSTOMIZED NGS

Depending on the patient’s heredity, the best strategy may be a customized test for more than one genetic disease or syndrome. For those with the most extensive and complex familial cancer histories, we even offer a comprehensive 60+ gene panel. Our lab has the capacity to sequence nine samples simultaneously, extracting only the relevant data from more than 6,800 genes.

COMMITMENT TO QUALITY

You are only as confident in a diagnosis or treatment recommendation as you are in the pathology behind it. To earn that confidence, we back our work with industry-leading quality control. All raw data is approved by the lab director before it is included in a report, and all final reports are co-signed by the lab director and a geneticist/physician to ensure they offer the most appropriate, actionable clinical interpretation of test results.

BOARD CERTIFIED GENETICISTS

Our laboratory offers two ABMGG board certified Geneticists, Marwan Tayeh, PhD.; Jeffrey Innis, MD, PhD and a board certified Genetic Counselor. We are committed to assisting clinicians in identifying genetic aberrations to facilitate clinical diagnosis, management and genetic counseling.