BRAC Mutation Panel
TESTING OPTION FOR BREAST, OVARIAN, PROSTATE, PANCREATIC CANCERS
BRCA Panel analysis can be performed on a patient who has a family history or is suspected of having breast, ovarian, prostate, or pancreatic cancer or for determining a genetic mutation for a patient with a clinical diagnosis of one of these cancers. Germline mutations in the BRCA1 and/or BRCA2 genes are associated with an increased risk for these cancers.
Factor V Leiden
MUTATION DETECTION FOR THROMBOPHILIA FOR BLOOD CLOTS DEVELOPMENT
Factor V Leiden thrombophilia is caused by a specific mutation in the F5 or Factor V gene. Most people with factor V Leiden thrombophilia have one "normal" F5 gene and one with the factor V Leiden gene mutation. Still, it is estimated that 95% of people with factor V Leiden never develop a clot.
Hereditary Breast and Ovarian Cancer (HBOC) Panel
Hereditary breast and ovarian cancer (HBOC) syndrome is an inherited cancer-predisposition syndrome that tends to affect both men and women (breast cancer) and woman (ovarian cancer) earlier in life, usually before the age of 50. Gene list: ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, STK11, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, PTEN, RAD51C, RAD51D, TP53, FANCC, XRCC2.
Hereditary Hemochromatosis Mutation
Mutation detection in candidate gene for hereditary hemochromatosis. Hereditary hemochromatosis is a disorder that causes the body to absorb excess iron, leading to overload and eventually damage tissues and organs. HFE gene has two common mutations, C282Y and H63D both of which are tested using PCR.
Colorectal Cancer Germline NGS Panel
TESTING FOR HEREDITARY NONPOLYPOSIS COLORECTAL CANCER (LYNCH SYNDROME)
Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is a genetic condition that is associated with a high risk of colon cancer and many other common cancers (stomach, small intestine, ovary, upper urinary tract, brain, etc.) Use for the detection of germline pathogenic variants in patients at increased risk for colon cancer. Gene list: APC, ATM, AXIN2, BMPR1A, CDH1, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53
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MEET DR. TAYEH
EXPERTISE DELIVERED PERSONALLY
Our quality commitment extends to how we communicate the results of our analyses. Our reports are developed with the right language and terminology to clarify complex data. I am available to answer questions and help providers prepare to discuss findings with patients and families. When more help is needed, clients can also connect with an MLabs board-certified genetic counselor.
Marwan Tayeh, Ph.D.
Associate Professor of Pediatric Genetics.
Director, Molecular Genetics
YOUR FIRST STEP TO CANCER DIAGNOSIS
MLabs offers state-of-the-science blood testing for inherited (germline) mutations impacting both adult and pediatric [LINK to Pediatric Molecular Genetics page] patients. These molecular signatures are used to make the most precise diagnosis possible, guiding patient-specific plans for prevention, treatment and monitoring.
Analytical platforms include Sanger DNA sequencing for an extensive list of genes, SNP chromosomal microarrays, relative-quantitative PCR, methylation analysis, MLPA, mutation screening panels (xTAG, Luminex) and SNP testing.
Next-generation sequencing (NGS) modalities make it possible identify multiple genetic mutations with excellent sensitivity and broad coverage with one test, while preserving the integrity of a specimen.
NGS multi-gene germline panels are available for the following cancer types:
- Breast and Ovarian Cancer
- Colorectal Cancer
- Endometrial/Uterine Cancer
- Melanoma Cancer
- Pancreatic Cancer
- Paraganglioma Cancer
- Prostate Cancer
- Renal Cancer
- Stomach Cancer
MOLECULAR AT ITS BEST
Depending on the patient’s heredity, the best strategy may be a customized test for more than one genetic disease or syndrome. For those with the most extensive and complex familial cancer histories, we even offer a comprehensive 60+ gene panel. Our lab has the capacity to sequence nine samples simultaneously, extracting only the relevant data from more than 6,800 genes.
COMMITMENT TO QUALITY
You are only as confident in a diagnosis or treatment recommendation as you are in the pathology behind it. To earn that confidence, we back our work with industry-leading quality control. All raw data is approved by the lab director before it is included in a report, and all final reports are co-signed by the lab director and a geneticist/physician to ensure they offer the most appropriate, actionable clinical interpretation of test results.
BOARD CERTIFIED GENETICISTS
Our laboratory offers two ABMGG board certified Geneticists, Marwan Tayeh, PhD.; Jeffrey Innis, MD, PhD and a board certified Genetic Counselor. We are committed to assisting clinicians in identifying genetic aberrations to facilitate clinical diagnosis, management and genetic counseling.
GRAB A COMPLETE GUIDE
The molecular services brochure covers details about our genetic, molecular oncology and translational services.
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