Days Set Up
Monday - Friday
Analytic Time

10 - 28 days (most tests signed out within 10 days after insurance authorization is received).

Soft Order Code
BRCA1/BRCA2/BRC1

Test Updated:

Synonyms

BRACAnalysis
Hereditary Breast and Ovarian Cancer (HBOC) Risk
BRCA1 and BRCA2 Gene Mutation
BRCA Tier 1
BRCA1
BRC1
BRCA2
BRCA1 Gene Sequencing
BRCA2 Gene Sequencing
Breast Cancer
Ovarian Cancer
Pancreatic Cancer
Prostate Cancer
Melanoma

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

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Test Overview

Test Methodology

The coding exons and flanking consensus splice sites of the BRCA1 or BRCA2 gene is amplified using specific primers, and bidirectionally sequenced using a fluorescent method.

Test Usage

BRCA1 or BRCA2 gene sequencing can be performed on a patient who has a family history or is suspected of having breast, ovarian, prostate, or pancreatic cancer or for determining a genetic mutation for a patient with a clinical diagnosis of one of these cancers. Individuals with BRCA2 mutations may also be at an increased risk for melanoma. Germline mutations in the BRCA2 gene are associated with an increased risk for these cancers. Incomplete penetrance as well as variable expressivity, variable age of onset and a wide-range of risk estimate have been reported in multiple families with BRCA1 and BRCA2 germline mutations (Levy-Lahad et al. Proc Natl Acad Sci 98:3232-3236, 2001; Antoniou et al. Am J Hum Genet 82:937-948, 2008).The lifetime risk for an individual with a pathogenic germline mutation in BRCA1 or BRCA2 has been estimated to be 40-80% for breast cancer and 11-40% for ovarian cancer. See http://www.ncbi.nlm.nih.gov/books/NBK1247/ for additional information.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Instructions

Please specify BRCA1 Gene Sequencing (BRCA1), BRCA2 Gene Sequencing (BRCA2), or both BRCA1 and BRCA2 Gene Sequencing (BRC1). Collect specimen in a lavender top tube. Send intact specimen within 24 hours if stored at room temperature or within 5 days if stored refrigerated. Include the patient's family history, pedigree, and ethnicity on the test requisition. Obtaining informed consent from the patient prior to genetic testing is strongly recommended. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained from the MMGL Molecular Genetics Laboratory by contacting the MLabs Client Services Center at 800-862-7284 or online at https://mlabs.umich.edu/sites/default/files/2020-01/file/pci-mmgl_infor….

Lavender Top Tube
Normal Volume
5 - 10 mL EDTA whole blood
Minimum Volume
5 mL EDTA whole blood

Billing Information

CPT Code
BRCA1: 81165; BRCA2: 81216; BRC1: 81163
Pro Fee Code
 
Insurance Auth Info
 
LOINC
 

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.