Days Set Up
Monday - Friday
Analytic Time

10 - 28 days (most tests signed out within 10 days after insurance authorization is received).

MiChart Code
BRCA Ashkenazi Jewish Founder Mutations (MMGL)
Soft Order Code
BRAJ

Test Updated:

Synonyms

BRAC2 gene c.5946delT (BIC: 6174delT)
Breast Cancer
BRCA1 gene c.68_69delAG (BIC: 185delAG)
BRCA1 gene c.5266dupC (BIC: 5382insC)
BRAJ

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

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Test Overview

Test Methodology

Targeted sequencing of the BRCA1 and BRCA2 genes is performed by amplifying the regions containing these founder mutations using specific primers, and bidirectionally sequencing them using a fluorescent method.

Test Usage

Three Ashkenazi Jewish founder mutations can be detected by this targeted sequencing assay: BRCA1 gene c.68_69delAG (BIC: 185delAG) and c.5266dupC (BIC: 5382insC) and one in BRCA2 c.5946delT (BIC: 6174delT). Note: MMGL will report out these mutations using the current Human Genome Variation Society (HGVS) naming guidelines instead of the previous nomenclature determined by Breast Cancer Information Core (BIC).

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Instructions

Collect specimen in a lavender top tube. Send intact specimen within 24 hours if stored at room temperature or within 5 days if stored refrigerated. Include the patient's family history, pedigree, and ethnicity on the test requisition. Obtaining informed consent from the patient prior to genetic testing is strongly recommended. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained from the MMGL Molecular Genetics Laboratory by contacting the MLabs Client Services Center at 800-862-7284 or online at https://mlabs.umich.edu/sites/default/files/2020-01/file/pci-mmgl_infor….

Lavender Top Tube
Normal Volume
5 - 10 mL EDTA whole blood
Minimum Volume
5 mL EDTA whole blood

Billing Information

CPT Code
81212
Pro Fee Code
 
Insurance Auth Info
 
LOINC
 

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.