Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
Looking to order a test?
We’ve provided helpful links to make ordering easy.Find a Requisition
All specimens should be accompanied by a requisition.Submitting Specimens
Learn about how to properly label and where to ship specimens.Order Kits and Supplies
MLabs provides all the supplies necessary for the collection of specimens.Test FAQ
Visit our provider FAQ and learn about common questions to ordering tests.
The entire coding sequences (exons plus 20 bp upstream and 20 bp downstream of each coding exon) of the targeted genes are captured, sequenced using NGS, and aligned to the human reference genome. A minimum NGS coverage of 20X for all coding exons is achieved. Copy Number variation is assessed by coverage depth within the targeted regions compared to a normalized set of controls. Copy number variants within the targeted regions that are of potential clinical significance will also be reported. All reported variants of potential clinical significance will be confirmed by a different technology or platform.
Use for the detection of germline pathogenic variants in patients at increased risk for colon cancer. Gene list: APC, ATM, AXIN2, BMPR1A, CDH1, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Collect specimen in a lavender top tube. Send intact specimen within 24 hours if stored at room temperature or within 5 days if stored refrigerated. Include the patient's family history, pedigree, and ethnicity on the test requisition. Obtaining informed consent from the patient prior to genetic testing is strongly recommended. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained from the MMGL Molecular Genetics Laboratory by contacting the MLabs Client Services Center at 800-862-7284 or online at https://mlabs.umich.edu/sites/default/files/2020-01/file/pci-mmgl_infor….