Days Set Up
Monday - Friday
Analytic Time

21 - 28 days

MiChart Code
TP53 Deletion / Duplication Analysis (MMGL
Soft Order Code

Test Updated:


Li-Fraumeni Syndrome (LFS)
Li-Fraumeni-Like Syndrome (LFL)
Sarcoma Family Syndrome of Li and Fraumeni
SBLA Syndrome
TP53 Deletion
TP53 Duplication

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

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Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

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Test Overview

Test Methodology

MLPA probes hybridize to target regions of the TP53 gene and are amplified by multiplex PCR. The amplification products are analyzed by capillary electrophoresis and copy numbers for these TP53 target regions are generated.

Test Usage

Analysis for the presence of TP53 (OMIM:191170) deletions or duplications in patients with a phenotype consistent with Li-Fraumeni syndrome (LFS) (OMIM:151623) or Li-Fraumeni-like syndrome (LFL).

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Collect specimen in a lavender top tube. Send intact specimen within 24 hours if stored at room temperature or within 5 days if stored refrigerated. Include the patient's family history, pedigree, and ethnicity on the test requisition. Obtaining informed consent from the patient prior to genetic testing is strongly recommended. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained from the MMGL Molecular Genetics Laboratory by contacting the MLabs Client Services Center at 800-862-7284 or online at….

Lavender Top Tube
Normal Volume
5 mL EDTA whole blood
Minimum Volume
2 mL EDTA whole blood

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.