21 - 28 days
KRAS test in inherited disease
Cardio Facio Cutaneous (CFC) Syndrome
v-Ki-Ras2 Kirsten Rat Sarcoma viral oncogene homolog Gene Sequencing
KRAS / KRAS2 Mutation Analysis
RASK / RASK2 Mutation Analysis
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The coding exons and associated, flanking splice sites of the KRAS gene are amplified using specific primers, and bidirectionally sequenced using a fluorescent method.
To detect the presence of KRAS mutations in patients with a diagnosis of Noonan syndrome, Cardio-facio-cutaneous (CFC) syndrome, or Costello syndrome, particularly if PTPN11 and SOS1 testing for Noonan syndrome was previously performed, and for carrier testing in families with a known KRAS mutation. All coding exons and associated flanking splice sites of the KRAS gene will be sequenced.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Collect specimen in a lavender top tube. Send intact specimen within 24 hours if stored at room temperature or within 5 days if stored refrigerated. Include the patient's family history, pedigree, and ethnicity on the test requisition. Obtaining informed consent from the patient prior to genetic testing is strongly recommended. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained from the MMGL Molecular Genetics Laboratory by contacting the MLabs Client Services Center at 800-862-7284 or online at https://mlabs.umich.edu/sites/default/files/2020-01/file/pci-mmgl_infor….