Days Set Up
Monday - Friday
Analytic Time

10 - 28 days (most tests signed out within 10 days after insurance authorization is received).

Soft Order Code

Test Updated:


BRCA Large Rearrangement Test (BART)
Myriad BRACAnalysis Large Rearrangement Test (BART) Equivalent
BRCA Tier 2
BRCA1 Gene Deletion and Duplication Analysis
BRCA1 Deletion
BRCA1 Duplication
BRCA2 Gene Deletion and Duplication Analysis
BRCA2 Deletion
BRCA2 Duplication
Prostate Cancer
Breast Cancer
Pancreatic Cancer
Ovarian Cancer

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

Visit our provider FAQ and learn about common questions to ordering tests.

Test Overview

Test Methodology

MLPA probes hybridize to target regions of the BRCA1 or BRCA2 gene and are amplified by multiplex PCR. The amplification products are analyzed by capillary electrophoresis and copy numbers for these BRCA1 or BRCA2 target regions are generated.

Test Usage

This test is used to detect the presence of BRCA1 (OMIM:113705) or BRCA2 (OMIM: 600185) deletions and duplications. BRCA gene deletion and duplication analysis can be performed on patients with no BRCA mutations detected by sequence analysis but have a clinical presentation consistent with BRCA-related disorders or on relatives of a patient with a known BRCA deletion/duplication mutation.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Please specify BRCA1 Deletion/Duplication (BRC1D), BRCA2 Deletion/Duplication (BRC2D), or both BRCA1 and BRCA2 Deletion/Duplication (BRC2). Collect specimen in a lavender top tube. Send intact specimen within 24 hours if stored at room temperature or within 5 days if stored refrigerated. Include the patient's family history, pedigree, and ethnicity on the test requisition. Obtaining informed consent from the patient prior to genetic testing is strongly recommended. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained from the MMGL Molecular Genetics Laboratory by contacting the MLabs Client Services Center at 800-862-7284 or online at….

Lavender Top Tube
Normal Volume
5 - 10 mL EDTA whole blood
Minimum Volume
5 mL EDTA whole blood

Billing Information

CPT Code
BRC1D: 81166; BRC2D: 81167; BRC2: 81164
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.