10 - 28 days (most tests signed out within 10 days after insurance authorization is received).
BRCA Large Rearrangement Test (BART)
Myriad BRACAnalysis Large Rearrangement Test (BART) Equivalent
BRCA Tier 2
BRCA1 Gene Deletion and Duplication Analysis
BRCA2 Gene Deletion and Duplication Analysis
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MLPA probes hybridize to target regions of the BRCA1 or BRCA2 gene and are amplified by multiplex PCR. The amplification products are analyzed by capillary electrophoresis and copy numbers for these BRCA1 or BRCA2 target regions are generated.
This test is used to detect the presence of BRCA1 (OMIM:113705) or BRCA2 (OMIM: 600185) deletions and duplications. BRCA gene deletion and duplication analysis can be performed on patients with no BRCA mutations detected by sequence analysis but have a clinical presentation consistent with BRCA-related disorders or on relatives of a patient with a known BRCA deletion/duplication mutation.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Please specify BRCA1 Deletion/Duplication (BRC1D), BRCA2 Deletion/Duplication (BRC2D), or both BRCA1 and BRCA2 Deletion/Duplication (BRC2). Collect specimen in a lavender top tube. Send intact specimen within 24 hours if stored at room temperature or within 5 days if stored refrigerated. Include the patient's family history, pedigree, and ethnicity on the test requisition. Obtaining informed consent from the patient prior to genetic testing is strongly recommended. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained from the MMGL Molecular Genetics Laboratory by contacting the MLabs Client Services Center at 800-862-7284 or online at https://mlabs.umich.edu/sites/default/files/2020-01/file/pci-mmgl_infor….