Allelic Discrimination, Polymerase Chain Reaction (PCR)
Prothrombin (Factor II) is the precursor of the serine protease thrombin, a key enzyme in the process of hemostasis and thrombosis, that exhibits procoagulant, anticoagulant and antifibrinolytic activities. One nucleotide change in the prothrombin gene – F2 c.*97G>A (rs1799963; g.46761055G>A; NC_000011.9; NM_000506.3; commonly referred to as 20210G>A), is associated with elevated prothrombin levels, an increased risk of venous thromboembolism and recurrent thromboembolism. Other genetic as well as environmental factors may also influence the risk of thrombosis. Genetic counseling may be indicated.
Interpretive report provided.
2 - 14 days
- Factor II Mutation Assay
- Prothrombin 20210 by DNA Analysis
- Prothrombin Promoter Mutation
- Prothrombin 20210 Mutation
- PROTHROMBIN 20210
- Prothrombin Progenitor Gene Test
Collect blood in a lavender top tube. Refrigerate and send intact blood specimen within 48 hours of collection.
To reduce inappropriate thrombophilia testing in the inpatient population this test has been removed from the inpatient test catalog. If there is a specific clinical need for this test on an inpatient please contact the Coagulation Laboratory.
By ordering this test the clinician acknowledges that informed consent has been obtained from the patient as required by applicable state or federal laws and the ordering clinician has authorization from the patient permitting MLabs to report the test results to the ordering clinician. Test includes pathologist interpretation of results billed as a separate additional charge. This test is not available without interpretation.