Test Overview
Test Methodology

A PCR-based assay, which includes HhaI digestion of the amplified product, is utilized to identify the 3 most common apolipoprotein E alleles (e2, e3, e4).

Test Usage

Determining the specific apolipoprotein E (APOE) genotypes in patients with type III hyperlipoproteinemia.

Reference Range *

Interpretive report provided. This test detects the Apo E2, E3, and E4 genes.

Test Limitations

This assay will not detect all of the mutations that cause type III hyperlipoproteinemia. Therefore, the absence of a detectable mutation does not rule out the possibility that an individual is a carrier of or affected with this disease. This assay cannot predict or rule out the development of Alzheimer disease in an individual. Rare polymorphisms exist that could lead to false-negative or false-positive results. If results obtained do not match the clinical findings, additional testing should be considered.

Test Details
Days Set Up
Friday
Analytic Time

5 - 10 days

Soft Order Code
APOEG
MiChart Code
Apolipoprotein E Genotyping
Synonyms
  • Apo E Genotyping
  • Apolipoprotein E Genotyping by DNA Analysis
  • Apo E2 Gene Detection
  • Apo E3 Gene Detection
  • Apo E4 Gene Detection
  • APOLIPOPROTEIN E GENOTYPE PCR
  • APOES
  • APOE
  • Apolipoprotein E Genotyping
  • MLABEL
Laboratory
Sendout
Reference Laboratory
Mayo APOEG
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect blood in a lavender top tube. Refrigerate and send intact blood within 48 hours of collection.

Alternate Specimen
ACD (yellow top) is acceptable.
Contraindications
In the absence of specific information regarding advances in the knowledge of mutation characteristics for a particular disorder, the current literature indicates that genetic tests for inherited disease need only be conducted once per lifetime.
Lavender Top Tube
Normal Volume
3 mL EDTA (lavender) whole blood
Additional Information

Test sent to Mayo Medical Laboratories. Specimens sent for Alzheimer's risk assessment are referred to Athena Diagnostics. The Apo E4 allele has been associated with an increased risk for late onset Alzheimer's dementia.

Billing
CPT Code
81401
LOINC
42315-2