Scientific and Clinical Research

May 15, 2024

Large Study Identifies Biomarkers for Rare Kidney Tumors

With 20 subtypes of Renal Cell Carcinoma (RCC) listed by the World Health Organization in 2022, determining the specific type of RCC and the correct treatment protocol for patients can be daunting. Only seven of the 20 subtypes had been defined by specific molecular changes and the 20% of RCCs that are classified as non-clear cell RCCs (non-ccRCC), were primarily identified only by histopathologic features.

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January 5, 2024

What is in your gut?

Dr. Gabriel Nuñez, the Paul de Kruif Professor of Pathology, and his laboratory colleagues recently published breakthrough research results in the journal Science , describing how his team identified new key roles of the gut’s microbiota in the development of colitis.

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November 29, 2023

Breakthrough in Defining pre-cancerous potential of Persistent Rhombic Lip (PeRL)

Medulloblastomas are one of the most common types of childhood brain cancer. Thanks to Dr. Sriram Venneti, MD, PhD and his colleagues, there has been a recent breakthrough in group-3 and group-4 medulloblastomas, a tumor that appears during fetal development of the cerebellum.

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November 21, 2023

Grant funds research into childhood blindness, new partnership in Turkey

A Global REACH seed grant aims to bridge stem cell biology and cutting-edge 3D retinal organoid technology to inform new research of childhood diseases that cause blindness. Rajesh C. Rao, M.D., Leonard G. Miller Professor of Ophthalmology and Visual Sciences, and Associate Professor of Human Genetics and Pathology, is a retina surgeon and physician-scientist.

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November 16, 2023

Study provides mechanistic link of diet to inhibition of colitis in Crohn's disease

Crohn’s disease (CD), one of the major forms of Inflammatory Bowel Disease, is a chronic relapsing intestinal disorder that affects millions of people globally. The cause of CD is unknown, but it is thought to result from a dysregulated immune response against environmental factors, including intestinal microbes, in genetically susceptible hosts.

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September 7, 2023

Dr. Paul Harms Discusses The Passing of a Legend from Merkel Cell Carcinoma

The death of singer/songwriter Jimmy Buffett brought sadness to those of us who grew up listening to his music and enjoying the beach vibe. Buffett died from a rare, but aggressive, form of skin cancer called Merkel cell carcinoma (MCC). This cancer usually appears as a rapidly growing flesh colored or reddish-blue nodule on sun-exposed skin.

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August 8, 2023

Study brings insight to kidney cancer with gene mutation

A study from clinicians and researchers at the University of Michigan Rogel Cancer Center, U-M Department of Pathology and the Michigan Center for Translational Pathology reveals findings from over 800 clinical assays performed for kidney patients with MiTF family gene mutations.

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August 4, 2023

Dr. Jeffrey B. Hodgin Among Team Awarded 2023 Global Team Science Award

Congratulations to Dr. Jeffrey B. Hodgin, MD, PhD who is among the team awarded the 2023 Global Team Science Award (GTSA) given by the Lupus Research Alliance (LRA). The GTSA is given to a team of multidisciplinary researcher experts who are identifying drivers of lupus nephritis in children with the goal of improving its diagnosis and treatment.

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January 25, 2023

Kim lab identifies the niche and mobilization mechanism for bone marrow innate lymphoid cell progenitors

The laboratory of Dr. Chang Kim, recently published a high-impact study that elucidates the bone marrow niche and mechanisms by which innate lymphoid cells differentiate between those which remain in the bone marrow and those which emigrate to the rest of the body.

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January 18, 2023

Study Published on Effectiveness of the Omicron Bivalent Booster

As the SARS-CoV-2 virus continues to mutate over time and new booster vaccines become available, the question arises, are the multivalent boosters more effective at improving immune response than the monovalent vaccines with which we began? This question was addressed by a multi-site group from Columbia University Vagelos College of Physicians and Surgeons (New York) and from the University of Michigan Medical School Department of Pathology.

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