July 8, 2024

Researchers find common immune system mechanism between pregnancy, cancer

To understand why some cancers successfully circumvent the immune system to grow unchecked, researchers turned to pregnancy. “In pregnancy, the immune system does not reject the growing fetus, so we know there must be mechanisms active in the placenta. In cancer, it’s the same thing: the growing tumor is not rejected by the immune system. It means the cancer cells have developed strategies to suppress immune rejection, same as in pregnancy,” said Weiping Zou, M.D., Ph.D., professor of experimental pathology.

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June 18, 2024

Engineering Hope

There are times in many people’s lives that can be called defining moments. Moments when their lives suddenly take a turn, and the entire trajectory of their lives change. This was true for Matthew Iyer, MD, PhD, Assistant Professor of Surgery and Pathology.

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June 11, 2024

AP-funded Grant Leads to Human Pathology Cover Story

The Division of Anatomic Pathology in the Michigan Medicine Department of Pathology offers grant funding for faculty and trainees to pursue research interests related to anatomic pathology that may not otherwise be funded. One of these internal AP grant-funded projects, led by first-author Eman Abdulfatah, MD and senior-author Rohit Mehra, MD, resulted in a recent cover story in Human Pathology entitled “Extragonadal germ cell tumors: A clinicopathologic study with emphasis on molecular features, clinical outcomes and associated secondary malignancies.”

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May 15, 2024

Large Study Identifies Biomarkers for Rare Kidney Tumors

With 20 subtypes of Renal Cell Carcinoma (RCC) listed by the World Health Organization in 2022, determining the specific type of RCC and the correct treatment protocol for patients can be daunting. Only seven of the 20 subtypes had been defined by specific molecular changes and the 20% of RCCs that are classified as non-clear cell RCCs (non-ccRCC), were primarily identified only by histopathologic features.

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January 5, 2024

What is in your gut?

Dr. Gabriel Nuñez, the Paul de Kruif Professor of Pathology, and his laboratory colleagues recently published breakthrough research results in the journal Science , describing how his team identified new key roles of the gut’s microbiota in the development of colitis.

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