Study Published on Effectiveness of the Omicron Bivalent Booster

As the SARS-CoV-2 virus continues to mutate over time and new booster vaccines become available, the question arises, are the multivalent boosters more effective at improving immune response than the monovalent vaccines with which we began? This question was addressed by a multi-site group from Columbia University Vagelos College of Physicians and Surgeons (New York) and from the University of Michigan Medical School Department of Pathology.

A New Cooperation between EZH2 and p38 Proteins Enhances Metastasis in Triple Negative Breast Cancer

The Celina Kleer lab at the University of Michigan Department of Pathology and Rogel Cancer Center has found a new mechanism that fuels metastasis in triple negative breast cancers. In their new study they show that EZH2, a master regulator of cell type identity, known to function through methylation of histones, has a new, unexpected function in aggressive breast cancers. By adding methyl groups to the p38 protein, EZH2 enhances the ability of breast cancer cells to spread to other tissue throughout the body, a process known as metastasis.

Qualitative Image Analysis Study Shows Excellent Results

A landmark study into quantitative image analysis in ER, PgR, and HER2 in invasive breast carcinoma was recently published in the American Journal of Clinical PathologyDr. Mustafa Yousif, Assistant Professor of Breast Pathology and Informatics, and colleagues conducted a retrospective study of 1,367 invasive breast carcinomas of all histopathology subtypes, for which ER, PgR, and HER2 were analyzed by manual scoring. These were compared to the results obtained using quantitative image analysis (QIA).  QIA uses a form of artificial intelligence (AI) called deep learning to identify specific regions of interest and to interpret that based on programmed algorithms.