A New Genome-Wide Tool for Detecting Cancer-Causing Rearrangements in Routine Lymphoma Biopsies

By Anastazia Hartman A collaborative team of researchers from the University of Michigan, New York University, and Arima Genomics has developed a new method that improves the detection of genomic rearrangements in lymphomas and multiple myeloma. The research, published this week in the journal Cell Genomics, was led by Russell Ryan, MD, of the University of Michigan Department of Pathology, and Matija Snuderl, MD, of the New York University Department of Pathology, in collaboration with Anthony Schmitt and colleagues at Arima Genomics, a biotechnology company that developed the assay, called

Targeting a metabolite as a therapy for childhood ependymomas

By Sriram Venneti Ependymomas are the third most common pediatric brain tumor, affecting roughly 250 children in the United States each year. Most cases are diagnosed in children eight years old or younger. Despite decades of research, current treatments extend survival but rarely cure the disease. A new study published in Nature by Dr. Sriram Venneti’s laboratory at the University of Michigan’s Department of Pathology and the Chad Carr Pediatric Brain Tumor Center has identified a surprising driver of ependymoma growth: a molecule called itaconate. The discovery opens the door to new