Test Overview
Test Methodology

Immunofluorescence (IFA); Western Blot if reflex is indicated

Test Usage

Purkinje Cell (Yo) antibody is found in approximately half of the patients with paraneoplastic cerebellar degeneration and is associated with ovarian, uterine, and small cell lung carcinomas and Hodgkin's lymphoma.

Reference Range *


* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday, Wednesday, Friday
Analytic Time

4 days

Soft Order Code
  • Sensory Neuropathy Antibody
  • Paraneoplastic Autoantibody, Purkinje Cell Cytoplastic Antibody
  • Paraneoplastic Cerebellar Degeneration (PCD)
  • Purkinje Cell Cytoplasmic Antibody
  • PCCA
  • Anti-Yo
  • PCA-1
Reference Laboratory
Quest Valencia (Quest SJC 90119)
Special Testing
Specimen Requirements
Collection Instructions

Collect blood in a red top tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Normal Volume
0.5 mL serum
Minimum Volume
0.2 mL serum
Additional Information

If the Yo Antibody screen by IFA is positive, Yo Antibody by Western Blot will be performed at an additional charge. If the Yo Antibody by Western Blot is positive, Yo Antibody Titer will be performed at an additional charge. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Test sent to Quest Diagnostics Nichols Institute of Valencia; performed by Quest San Juan Capistrano.

CPT Code
Fee Code
Reflex CPT
Western Blot: 84181, Titer: 86256.