Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Monitoring peak levels of voriconazole, especially in individuals with reduced liver function, individuals with CYP2C19 polymorphisms associated with poor metabolic funtion, or individuals taking medications that affect CYP2C19 activity.
1.0 - 5.5 mcg/mL
Voriconazole metabolism may be altered by coadministration of drugs that metabolically induce or inhibit CYP2C19 or by genetic polymorphisms that affect enzyme activity.
2 - 3 days
- Voriconazole Level
Collect specimen in a red top tube; do not use SST tube. Centrifuge within 2 hours of draw, aliquot serum into a plastic vial and refrigerate.
Test sent to Mayo Clinic Laboratories.