Test Overview

Test Methodology

Latex Agglutination

Test Usage

Aid with the diagnosis of von Willebrand disease.

Reference Range*

50 - 150%

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

vWF disease necessitates a series of clinical and laboratory evaluations including patient and family history, vWF activity, factor VIII activity, and von Willebrand factor antigen.

Test Details

Days Test Performed

Friday

Analytic Time

1 hour

Soft Order Code

VWAGN

MiChart Code

Von Willebrand Antigen

Synonyms

Synonyms

Coagulation Factor VIII Related Antigen
Factor VIII Related Antigen
von Willebrand's Antigen
VWF AGN
VONWILLEBRAND'S FACTOR ANTIGEN
Factor VIII Antigen
VWAGN

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Laboratory

Hematopathology

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 3 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.

Rejection Criteria

Specimens will be rejected if not properly filled, clotted, grossly hemolyzed, or contaminated with heparin.

Container

Blue Top Tube

Normal Volume

Full 2.7mL tube or 1mL plasma aliquot

Minimum Volume

Full 1.8mL tube or 1mL plasma aliquot

Additional Information

VWF is an acute phase reactant. Elevated levels are seen during pregnancy, estrogen therapy, inflammation, acute infection, post surgery, physical exercise, or a stressful situation. Individuals with type O blood group have lower levels of vWF compared to other blood groups. In classical hemophilia, von Willebrand factor antigen levels are normal or increased, whereas in type I von Willebrand disease, the levels are very low or undetectable. Von Willebrand factor antigen levels may be normal in von Willebrand variants.

Billing Information

Fee Codes


CPT Code

85246

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