Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)
Evaluate catecholamine production, useful in the diagnosis of pheochromocytoma and neuroblastoma and in confirmation of elevated catecholamine levels.
24 Hour Urine - VMA:
0-1 years: 0 - 1.5 mg/24 hours
1-3 years: 0 - 1.5 mg/24 hours
3-5 years: 0 - 4.0 mg/24 hours
5-10 years: 0 - 4.0 mg/24 hours
10-127 years: 0 - 10.0 mg/24 hours
Random Urine - VMA / Creatinine Ratio:
0-1 years: < 18 mg/gm creatinine
1-3 years: < 12 mg/gm creatinine
3-5 years: < 12 mg/gm creatinine
5-10 years: < 9 mg/gm creatinine
10-127 years: < 8 mg/gm creatinine
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
False elevations may occur if patients do not follow the VMA preparation instructions.
- VANILLYLMANDELIC ACID, (VMA)
Collect 24 hour urine specimen. Add 25 mL of 50% glacial acetic acid (15 mL for pediatric patients) to container prior to start of collection. Following collection, mix well, measure 24 hour urine volume, aliquot 10 mL into a plastic urine container and refrigerate. Record total 24 hour urine volume and collection dates/times on request form. Specimens with no preservative are also acceptable: add 50% glacial acetic acid to container following collection, mix well and send 10 mL aliquot (preferred); alternatively a non-acidified aliquot will be accepted. Patient should avoid medications, chocolate, fruit, bananas and any vanilla containing substances for 48 hrs prior to beginning collection. Random samples will be accepted on children less than 10 years old, in which case the VMAR test code must be ordered instead of the VMA test code.
MLABS: Random specimen has been approved for all ages for clients. [4/98]
Tested using a laboratory developed assay performed on a Waters liquid chromatography tandem mass spectrometry (LC-MS/MS) system. Results determined from different manufacturers and/or methods may not be comparable.