Test Overview
Test Methodology

Liquid Chromatography - Mass Spectrometry (LC-MS)

Test Usage

Evaluate catecholamine production, useful in the diagnosis of pheochromocytoma and neuroblastoma and in confirmation of elevated catecholamine levels.

Reference Range *

24 Hour Urine: VMA: 0-2 years: 0-1.5 mg/24 hrs, 3-9 years: 0-4.0 mg/24 hrs, 10-150 years: 0-10.0 mg/24 hrs; Random Urine: VMA/Creatinine Ratio:

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

False elevations may occur if patients do not follow the VMA preparation instructions.

Test Details
Days Set Up
Weekly
Analytic Time

8 hours

Soft Order Code
VMA/VMAR
MiChart Code
VMA, 24HR Urine
Synonyms
  • VMA
  • VANILLYLMANDELIC ACID, (VMA)
Laboratory
Chemical Pathology
Section
Drug Analysis
Specimen Requirements
Collection Instructions

Collect 24 hour urine specimen. Add 25 mL of 50% glacial acetic acid (15 mL for pediatric patients) to container prior to start of collection. Following collection, mix well, measure 24 hour urine volume, aliquot 10 mL into a plastic urine container and refrigerate. Record total 24 hour urine volume and collection dates/times on request form. Specimens with no preservative are also acceptable: add 50% glacial acetic acid to container following collection, mix well and send 10 mL aliquot (preferred); alternatively a non-acidified aliquot will be accepted. Patient should avoid medications, chocolate, fruit, bananas and any vanilla containing substances for 48 hrs prior to beginning collection. Random samples will be accepted on children less than 10 years old, in which case the VMAR test code must be ordered instead of the VMA test code.

Alternate Specimen
May be collected in plain (no preservative) container and acid added at the end of collection. It is preferred to have acid added as soon as possible at the client site, mixed, and an aliquot sent. A non-acidified aliquot may also be sent. [rev 9/08] Random samples will be accepted on children less than 10 years old, in which case the VMAR test code must be ordered instead of the VMA test code.
MLABS: Random specimen has been approved for all ages for clients. [4/98]
Contraindications
Patient should avoid medications, chocolate, fruit, bananas and any vanilla containing substances for 48 hrs prior to and during collection.
Red Top Tube
Normal Volume
10 mL aliquot of 24 hour urine collection, 6 mL of a random collection.
Minimum Volume
4 mL aliquot of 24 hour urine collection, 4 mL of a random collection.
Billing
CPT Code
84585
Fee Code
36902
LOINC
3122-9
Resources