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Chromogenic Substrate Assay
Used to monitor treatment with unfractionated (standard) heparin. Specifically for patients with history of Eliquis (Apixaban) or Xarelto (Rivaroxaban) therapy.
Due to concurrent or recent therapy with an Anti-Xa inhibitor, the UNFH is measured by an Anti-IIa Assay.
The therapeutic range for the Adult ACS/AFib and stroke nomograms is 0.2-0.5 IU/mL. The therapeutic range for the Adult DVT/PE nomogram is 0.3-0.7 IU/mL. Patients not being followed with the Adult UMHS nomogram, the therapeutic range for unfractionated heparin is 0.3 to 0.7 IU/mL
Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within one hour of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 1 hour of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.