Test Overview

Test Methodology


Test Usage

Evaluation of patients with suspected systemic infection, in particular infection caused by gram-negative bacteria detection and for evaluation of patients with suspected chronic inflammatory disorders, such as rheumatoid arthritis, inflammatory bowel disease, or ankylosing spondylitis.

Reference Range*

< or =2.8 pg/mL

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Tumor necrosis factor (TNF)-alpha is a nonspecific marker associated with an inflammatory response, and is not diagnostic for any specific disease or disease process. Elevated concentrations of TNF-alpha must be interpreted within the clinical context of the patient. Normal concentrations of TNF-alpha do not exclude the possibility of an ongoing inflammatory process.

Test Details

Days Test Performed


Analytic Time

2 - 9 days

Soft Order Code


MiChart Code

Tumor Necrosis Factor - Alpha



alpha-Tumor Necrosis Factor
TNF-Alpha, Highly Sensitive

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Laboratory Reference


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Specimen Requirements

Offsite Collection Instructions

Collect specimen in a lavender top tube and immediately place on wet ice. Centrifuge, aliquot serum into a plastic vial and freeze within 30 minutes of collection.


Lavender Top Tube

Normal Volume

0.5 mL serum

Minimum Volume

0.3 mL serum

Additional Information

Test sent to Mayo Medical Laboratories.

Billing Information

Fee Codes

CPT Code


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