Test Overview

Test Methodology

Electrochemiluminescent Immunoassy

Test Usage

Marker of myocardial injury. Aid in the rule in / rule out of acute coronary syndrome (ACS). Useful in monitoring and prognosis in patients with ACS.
Troponin T is one of three proteins of the troponin complex that regulates the calcium mediated interaction of actin and myosin. Plasma levels of Trop T begin to rise within several hours after an acute myocardial infarction, with peak concentrations being reached in approximately 12-18 hours after infarction. Troponin T levels can remain elevated in plasma for 5 to 7 days before returning to normal. Because it is a marker of myocardial injury, Troponin T may be elevated in a number of cardiac conditions other than AMI, including unstable angina, congestive heart failure, end-stage renal disease, septic shock, hypertension, cardiomyopathy, myocarditis, pulmonary embolism, and tachyarrythmias.
The 99%ile of a normal population for this Trop T assay is 19 pg/mL. For patients who present with suspected ACS, a Trop T value > 19pg/mL with a rising pattern in serial samples is suggestive of ACS. Serial measurements are highly recommended for the diagnosis or exclusion of ACS. For rule in or rule out on an inpatient unit, samples drawn 3 to 4 hours apart showing a difference or delta value of greater than 6 pg/mL is considered consistent with acute myocardial injury. A decrease in Trop T over time can indicate an acute injury that occurred days ago, but in general is less specific for ACS and more often associated with non-ACS conditions. Chronic conditions that can produce an elevation of Trop T will rarely show a significant delta over time intervals of 2 to 6 hours.
Clearance of Troponin T can be prolonged in patients with a decreased eGFR.
For more information, please view the educational material:
[link text="High Sensitivity Troponin T Education" href="/static/apps/handbook/pdfs/high-sensitivity-troponin-t-education.pdf"]

Reference Range*

<19 pg/mL

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details

Days Test Performed

Daily, 24 hours

Analytic Time

1 hour

Soft Order Code

HTRPT

MiChart Code

Troponin T 5th Generation high-sensitivity assay

Laboratory

Chemical Pathology

STAT Availability

STAT requests for this test will be performed on a STAT basis (supervisory staff approval is not required).

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in a light green top plasma separator gel tube. Centrifuge and refrigerate.

Rejection Criteria

Hemolyzed specimens are not acceptable for analysis.

Normal Volume

0.5 mL plasma

Minimum Volume

0.25 mL plasma

Billing Information

Fee Codes


CPT Code

84484

LOINC

67151-1

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