Test Overview
Test Methodology

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Test Usage

Monitoring metallic prosthetic implant wear.

Reference Range *

<2 ng/mL

Test Limitations

Titanium is a trace metal commonly used in alloys and readily present in the environment. Thus, contamination of the collection site and of the specimen must be avoided. Failure to use metal-free collection procedures and devices may cause falsely increased results.

Test Details
Days Set Up
Analytic Time

1 - 7 days

Soft Order Code
MiChart Code
Titanium, Serum
  • TIS
  • Titanium, Serum
  • Ti (Titanium), Serum
Reference Laboratory
Mayo TIS (89367)
Special Testing
Specimen Requirements

Royal blue (trace element) and/or Metal-Free aliquot tubes are available from MLabs (800-862-7284). Collect blood in a royal blue top (trace element) tube with no preservative (serum). Allow specimen to clot for 30 minutes, centrifuge, and carefully pour serum into a metal-free aliquot tube, avoiding transfer of the cellular components of blood. Do not insert a pipet into the serum to transfer and do not ream the specimen with a wooden stick to assist with the transfer. Refrigerate up to 48 hours or freeze for longer storage. Do not collect specimens for trace metal testing from patients who have received gadolinium-, iodine-, or barium-containing contrast material within the past 96 hours. These metal-based contrast agents are known to interfere with laboratory techniques commonly used for trace metals analysis.

High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Normal Volume
1.2 mL serum
Minimum Volume
0.8 mL serum
Storage Temperature
Refrigerated (preferred): 28 days, Ambient: 7 days, Frozen: 28 days.
Additional Information

Test sent to Mayo Medical Laboratories.

CPT Code
Fee Code
NY State Approved