Test Overview
Test Methodology

Multiplex Flow Immunoassay

Test Usage

Marker of celiac disease associated with gluten-sensitive enteropathy or dermatitis herpetiformis. A positive result indicates the presence of human-tTG IgG antibodies and suggests the possibility of certain gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis.

Reference Range *

Negative (0-14 U/mL)

Test Limitations

The presence of immune complexes or other immunoglobulin aggregates in the patient sample may cause an increased level of non-specific binding and produce false positives in this assay. IgG antibody is more sensitive but less specific than IgA antibody. Since IgA deficiency is relatively common among celiac patients, the combined use of IgA and IgG antibodies is recommended for diagnosis. Hemolytic samples may cause results to be inaccurate due to hemolysis interferent.

Test Details
Days Set Up
M-F
Analytic Time

8 hours

Soft Order Code
TTGG
MiChart Code
Tissue Transglutaminase, IgG
Synonyms
  • Celiac Disease Antibody
  • Celiac Disease Panel
  • Celiac Disease, Tissue Transglutaminase IgG
  • Celiac Sprue panel
  • Gluten Sensitivity, Tissue Transglutaminase IgG
  • Gluten-sensitive Antibody
  • Transglutaminase, Tissue IgG
  • tTG
  • tTG, IgG
  • TTGG
  • TISSUE TRANSGLUTAMINASE IGG AB
  • TTRGG
  • Tissue Transglutaminase IgG AB
Laboratory
Chemical Pathology
Section
Immunopathology
Specimen Requirements
Collection Instructions

Collect specimen in SST tube, avoid hemolysis. Centrifuge, aliquot serum into a plastic vial and refrigerate. Store at 2-8?C up to 7 days. For longer storage freeze at -20?C.

Alternate Specimen
Red top tube.
Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.2 mL serum
Additional Information

Tissue Transglutaminase IgA and IgG Antibodies may be ordered together or separately. If the antibody is not clearly specified, both the IgA and IgG assays will be performed. Please contact the MLabs Client Services Center for additional clinical information regarding Celiac Disease and associated laboratory testing.

Billing
CPT Code
83516
Fee Code
35604
LOINC
53026-1
NY State Approved
No