Test Overview
Test Methodology

Multiplex Flow Immunoassay

Test Usage

Marker of celiac disease associated with gluten-sensitive enteropathy or dermatitis herpetiformis. A positive result indicates the presence of human-tTG IgA antibodies and suggests the possibility of certain gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis.

Reference Range *

Negative (0-14 U/mL)

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

The presence of immune complexes or other immunoglobulin aggregates in the patient sample may cause an increased level of non-specific binding and produce false positives in this assay. IgA antibody is more specific but less sensitive than IgG antibody. Since IgA deficiency is relatively common among celiac patients, the combined use of IgA and IgG antibodies is recommended for diagnosis. Hemolytic samples may cause results to be inaccurate due to hemolysis interferent. Results are unreliable in patients with extremely low total IgA values.

Test Details
Days Set Up
Analytic Time

8 hours

Soft Order Code
MiChart Code
Tissue Transglutaminase, IgA
  • Celiac Disease Antibody
  • Celiac Disease Panel
  • Celiac Disease, Tissue Transglutaminase IgA
  • Celiac Sprue panel
  • Gluten Sensitivity, Tissue Transglutaminase IgA
  • Gluten-sensitive Antibody
  • Transglutaminase, Tissue IgA
  • tTG
  • tTG, IgA
  • TTGA
  • Tissue Transglutaminase IgA AB
Chemical Pathology
Specimen Requirements
Collection Instructions

Collect specimen in SST tube, avoid hemolysis . Centrifuge, aliquot serum into a plastic vial and refrigerate. Store at 2-8?C up to 7 days. For longer storage freeze at -20?C.

Alternate Specimen
Red top tube.
Normal Volume
0.5 mL serum
Minimum Volume
0.2 mL serum
Additional Information

Tissue Transglutaminase IgA and IgG Antibodies may be ordered together or separately. If the antibody is not clearly specified, both the IgA and IgG assays will be performed. Please contact the MLabs Client Services Center for additional clinical information regarding Celiac Disease and associated laboratory testing.

CPT Code
Fee Code
46128-5, 35280-7