The presence of immune complexes or other immunoglobulin aggregates in the patient sample may cause an increased level of non-specific binding and produce false positives in this assay. IgA antibody is more specific but less sensitive than IgG antibody. Since IgA deficiency is relatively common among celiac patients, the combined use of IgA and IgG antibodies is recommended for diagnosis. Hemolytic samples may cause results to be inaccurate due to hemolysis interferent. Results are unreliable in patients with extremely low total IgA values.