Test Overview
Test Methodology

see individual tests

Test Usage

Comprehensive study to determine causes of venous thrombosis.

Reference Range *

Interpretive report provided for abnormal results

Test Limitations

see individual tests

Test Details
Days Set Up
Varies
Analytic Time

7 days

Soft Order Code
PROTH
MiChart Code
Thrombotic Risk (Hypercoag) Profile
Synonyms
  • PROTHROMBOTIC (ON COUMADIN)
  • PROTHROMBOTIC (NO COUMADIN)
  • HEXAG
  • PROTHROMBIN TIME
  • Partial Thromboplastin Time
  • DILUTE RUSSELL'S VIPER VENOM
  • Hexagonal phospholipid neut
  • PROTH-NO C
  • PROTH-C
  • HYPERCOAG
  • Thrombosis Profile
  • APCR
  • AT3
  • F8
  • FIB
  • FIB AGN
  • PCA
  • PLASMINOGE
  • PSAGF
  • PT7
  • PTT
  • DRVVT
  • FACTOR VIII ASSAY
  • ANTITHROMBIN III ACTIVITY
  • Hypercoagulability
  • Prothrombotic Evaluation
  • Activated Protein C Resistance
  • FIBRINOGEN
  • FIBRINOGEN ANTIGEN
  • PROTEIN C ACTIVITY
  • PLASMINOGEN ACTIVITY
  • PROTEIN S ANTIGEN FREE
Laboratory
Hematopathology
Section
Coagulation
Specimen Requirements
Collection Instructions

Collect specimen in 7 blue top (citrate 3.2%) tubes. Mix by inversion. Specimen should arrive at lab within 3 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into 7 plastic tubes, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.

Please provide clinical history (brief description of the reason for testing, e.g., history of easy bruising and menorrhagia, family history of von Willebrand disease) and a listing of current and recent medications, including oral contraceptives, anticoagulants, and factor replacement therapy/DDAVP.

Special Handling

To reduce inappropriate thrombophilia testing in the inpatient population this test has been removed from the inpatient test catalog. If there is a specific clinical need for this test on an inpatient please contact the Coagulation Laboratory.

Rejection Criteria
Specimens will be rejected if not properly filled, clotted, grossly hemolyzed, or contaminated with heparin.
Contraindications
Not indicated for patients receiving anticoagulant therapy, or immediately following an acute thrombotic event. This test is not indicated for inpatient evaluation of acute thrombosis.
Blue Top Tube
Normal Volume
7 full 2.7mL tubes or 7mL plasma (seven 1mL aliquots)
Minimum Volume
7 full 1.8mL tubes or 7mL plasma (seven 1mL aliquots)
Storage Temperature
Room temperature for whole blood or frozen aliquot of citrated plasma
Additional Information

Panel includes PT (Prothrombin Time), PTT (Activated Partial Thromboplastin Time), Antithrombin III Activity, Factor VIII Assay, Fibrinogen (clottable), Fibrinogen Antigen, Plasminogen Activity, Protein C Activity, Protein S Antigen (Free), Activated Protein C Resistance, Hexagonal Phospholipid Neutralization, and Dilute Russell's Viper Venom Test. The following tests are not included in the profile, but may also be considered as part of an evaluation for a prothrombic state: Cardiolipin Antibody, Plasma Homocysteine, and Prothrombin 20210 Mutation Detection. Test may include pathologist interpretation of results at an additional charge. By ordering this test, the clinician acknowledges that a pathologist interpretation will be performed and billed as a separate additional charge if indicated.

Billing
CPT Code
85610, 85730, 85240, 85300, 85420, 85384, 85385, 85303, 85306, 85307, 85613, 85598
Fee Code
31102, 31105, 31106, 31107, 31113, 31115. 31122, 31127, 31137, 31141, 31143, 36566
Pro Fee CPT
85390
NY State Approved
No