Test Overview
Test Methodology

HPLC

Test Usage

Used to individualize dosing and balance therapeutic response with possible toxicity for patients on thiopurine therapy. Provides measurement of 6-TG (correlated with clinical response and leukopenia) and 6-MMP (correlated with hepatotoxicity) metabolites. Metabolite testing shuld not replace laboratory monitoring for toxicity.

Reference Range *

6-TGN: 235 - 400 pmole/8x10(8) RBC, 6-MMPN: <5700 pmole/8x10(8) RBC.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Analytic Time

14 days

Soft Order Code
6MMP
MiChart Code
Thiopurine Metabolites, 6-TG and 6-MMP
Synonyms
  • 6MMP and 6TG
  • 6MMP
  • 6 Thioguanine (6 TG)
  • 6 Methyl Mercaptopurine (6 MMP)
  • PRO-PredictRx Metabolites
  • Thiopurine Metabolites
  • Imuran Metabolites
Laboratory
Sendout
Reference Laboratory
Prometheus 3200
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a lavender top tube. Refrigerate and send intact specimen within 5 days of collection. Do not freeze.

Normal Volume
5 mL EDTA whole blood
Minimum Volume
3 mL EDTA whole blood
Additional Information

Test sent to Prometheus Labs.

Billing
CPT Code
82542
Fee Code
AA225