Evaluate thiocyanate toxicity, nitroprusside poisoning
Normal: Negative; Therapeutic: 0.6-2.9 mg/dL (103-499 uMol/L); Toxic: greater than 3.5 mg/dL (greater than 602 uMol/L), Critical: greater than 10.0 mg/dL (greater than 1720 uMol/L)
Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic container and refrigerate.
Nitroprusside (Nipride) is an antihypertensive agent; it produces cyanogen (CN) in the body which is rapidly detoxified to thiocyanate in the liver. The half-life of thiocyanate is 7 days. Toxic manifestations are psychotic behavior, agitation and convulsions.