Test Overview
Fluorescence In Situ Hybridization (FISH)
This test detects rearrangements involving the TFEB gene region (6p21) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using a dual-color break-apart probe (Empire Genomics) to qualitatively assess for the presence of TFEB translocations that are associated with certain subtypes of renal cell carcinoma. Testing for TFEB gene rearrangement may aid in the diagnosis and classification of these tumors.
Interpretive report provided.
This test detects rearrangements involving TFEB, however it will not identify the translocation partner.
Test Details
10-14 days
- TFEB gene region 6p21
- CGTFB
- FFPE FISH for TFEB
- Renal Cell Carcinoma
Specimen Requirements
Submit a formalin-fixed, paraffin block of the renal tumor tissue (with matched benign renal tissue if available); store at room temperature.
Additional Information
By ordering this test the clinician acknowledges that informed consent has been obtained from the patient as required by applicable state or federal laws. Test includes pathologist interpretation of results billed as a separate additional charge. This test is not available without interpretation.