Test Overview
Test Methodology

Fluorescence In Situ Hybridization (FISH)

Test Usage

This test detects rearrangements involving the TFEB gene region (6p21) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using a dual-color break-apart probe (Empire Genomics) to qualitatively assess for the presence of TFEB translocations that are associated with certain subtypes of renal cell carcinoma. Testing for TFEB gene rearrangement may aid in the diagnosis and classification of these tumors.

Reference Range *

Interpretive report provided.

Test Limitations

This test detects rearrangements involving TFEB, however it will not identify the translocation partner.

Test Details
Days Set Up
Monday - Friday, 8:00am - 4:00pm
Analytic Time

10-14 days

Soft Order Code
CGTFB
MiChart Code
TFEB Rearrangement by FISH
Synonyms
  • TFEB gene region 6p21
  • CGTFB
  • FFPE FISH for TFEB
  • Renal Cell Carcinoma
Laboratory
Cytogenetics
Section
Cytogenetics
Specimen Requirements
Collection Instructions

Submit a formalin-fixed, paraffin block of the renal tumor tissue (with matched benign renal tissue if available); store at room temperature.

Additional Information

By ordering this test the clinician acknowledges that informed consent has been obtained from the patient as required by applicable state or federal laws. Test includes pathologist interpretation of results billed as a separate additional charge. This test is not available without interpretation.

Billing
CPT Code
88377-TC
Fee Code
EA022
Pro Fee CPT
88377-26
NY State Approved
No