Test Overview
Fluorescence In Situ Hybridization (FISH)
This test detects rearrangements involving the TFE3 gene region (Xp11.2) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using a dual-color break-apart probe (Empire Genomics) to qualitatively assess for the presence of TFE3 translocations that are associated with certain subtypes of renal cell carcinoma. Testing for TFE3 gene rearrangement may aid in the diagnosis and classification of renal tumors.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
This test detects rearrangements involving TFE3, however it will not identify the translocation partner.
Test Details
10-14 days
- CGTF3
- Renal Cell Carcinoma
- FFPE FISH for TFE3
- TFE3 gene region Xp11.2
Specimen Requirements
Submit a formalin-fixed, paraffin block of the renal tumor tissue (with matched benign renal tissue if available); store at room temperature.
Additional Information
By ordering this test the clinician acknowledges that informed consent has been obtained from the patient as required by applicable state or federal laws.