3 - 10 days
Gene Rearrangement, TCRbeta
T Cell Gene Rearrangement
Gene Rearrangement, T Cell
TCR Beta GR by PCR (TRB by PCR)
Gene Rearrangement, T-Cell
T Cell Beta Gene Rearrangement
TRB Gene Rearrangement
TCRbeta Gene Rearrangement
T cell antigen receptor, beta, Gene Rearrangement
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Polymerase Chain Reaction (PCR) with capillary electrophoresis
T cell lymphoproliferative disorders are frequently associated with clonal rearrangements of the T cell receptor beta (TRB) locus. Evaluation of the TRB locus may occasionally demonstrate clonal rearrangements not detected by T cell receptor gamma (TRG) testing. This test employs multiplexed PCR primers to detect gene rearrangements involving the variable and joining regions and diversity and joining regions of the TRB locus. In conjunction with clinical, morphologic and immunophenotypic data, the detection of these clonal rearrangements may be useful in the distinction of a lymphoproliferative disorder from a non-neoplastic process. In addition, the comparison of rearrangements detected within lymphocytic infiltrates from separate samples may be useful in determining their clonal relationship. The clinical implications of gene rearrangement results must always be interpreted in the context of the individual patient’s clinicopathologic presentation.
*Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Collect blood or bone marrow in a lavender top tube. Refrigerate and send intact blood or bone marrow specimen within 48 hours of collection. Fresh tissue (preferably 0.5cm3, sent in RPMI) and fresh aspirates or body fluids are acceptable. Refrigerate and send, preferably within 24 hours. Frozen tissue specimens – preferably frozen with 1 hour of collection – may also be sent frozen on dry ice. Fresh cell suspensions in RPMI should be refrigerated and sent, preferably within 48 hours. Frozen cell suspensions – preferably frozen with 1 hour of collection – may also be sent frozen on dry ice. For formalin-fixed, paraffin-embedded tissue, a tissue block is preferred. Unstained, UNBAKED slides (5-8, 10-micron slides; 10-15 if few neoplastic cells are present) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.