Test Overview
Nontreponemal flocculation procedure (RPR).
Neonatal evaluation for syphilis, with reflex titer.
Non-reactive
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Nonspecific positive reactions may be found in SLE, malaria, infectious mononucleosis, hepatitis, leprosy, brucellosis, atypical pneumonia, typhus, and other infections. Reactive tests due to related treponemal infections (bejel, pinta, or yaws) may also occur. A reactive result in a newborn may be due to passive transfer from mother's blood.
Test Details
8 hours
Specimen Requirements
Collect specimen in SST tube. Centrifuge, aliquot serum into plastic vial and refrigerate.
Plasma, EDTA, heparin.
Additional Information
Reactive specimens will be titered (RPRQN). The more specific TPPA test will not be performed In untreated syphilis, reactive sera are found in the chancre stage 30% after one week and 90% after three weeks. In the secondary stage, the RPR should be reactive 100% of the time, decreasing to 90% in the tertiary stage. In the latent stage and after successful treatment, the RPR may become nonreactive. The titer of antibody will vary from patient to patient. There is no direct relationship between the amount of reagin and the severity of disease. A patient's peak titer will usually occur during the secondary stage, then decrease and plateau during later stages. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated.