Test Overview
Test Methodology

Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS) Stable Isotope Dilution Analysis

Test Usage

Confirming the presence of synthetic glucocorticoids. Confirming the cause of secondary adrenal insufficiency.

Reference Range *


* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

This method cannot detect all of the available synthetic steroids either available as pharmaceutical compounds or chemicals present in food. Lack of detection does not preclude use of synthetic glucocorticoids because adrenal suppression may persist for some time after the exogenous steroid is discontinued.

Test Details
Days Set Up
Tuesday, Thrusday
Analytic Time

2 - 7 days

Soft Order Code
MiChart Code
Synthetic Glucocorticoid Screen Serum (Sendout)
  • Beclomethasone dipropionate
  • Betamethasone
  • Budesonide
  • Dexamethasone
  • Fludrocortisone
  • Flunisolide
  • Fluorometholone
  • Fluticasone propionate
  • Megestrol acetate
  • Methylprednisolone
  • Prednisolone
  • Prednisone
  • Triamcinolone
  • Triamcinolone acetonide
  • Synthetic Steroid Screen, Serum
  • SGSS
Reference Laboratory
Mayo SGSS (81031)
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial and freeze.

Normal Volume
2 mL serum
Minimum Volume
1.1 mL serum
Additional Information

This test screens for and quantitates if present, the following synthetic glucocorticoids: beclomethasone dipropionate, betamethasone, budesonide, dexamethasone, fludrocortisone, flunisolide, fluorometholone, fluticasone propionate, megestrol acetate, methylprednisolone, prednisolone, prednisone, triamcinolone, triamcinolone acetonide. Test sent to Mayo Medical Laboratories.

CPT Code
Fee Code