Test Overview
Test Methodology


Test Usage

Synovasure® Alpha Defensin test results are intended to be used in conjunction with other clinical and diagnostic findings to aid a patient’s diagnosis. Synovasure® Alpha Defensin is intended to determine whether there is an infection present in the synovial fluid of a joint. Results do not identify a specific type of infection or establish the origin or severity of an infection. Results provide a physician with a specific positive or negative indication for the presence of the alpha defensin biomarker that is released into the synovial fluid by the patient’s cells while fighting an infection.

Reference Range *

Alpha Defensin Negative
CRP < 3 mg/L for the PJI test and < 7.5 mg/L in the NSA test
Hemoglobin < 20 g/L

Test Details
Days Set Up
Monday - Friday
Analytic Time

2 - 5 days

Soft Order Code
MiChart Code
  • Alpha Defensins, Synovial Fluid
Reference Laboratory
Citrano Diagnostic Labs
Special Testing
Specimen Requirements
Collection Instructions

Collect aspirate from affected joint. Aspirate must must put into a plain red top tube. Send to Specimen Processing at ambient temperature. Please indicate if fluid was collected from a non-replacement joint (native) (SYNOS) or from a prosthetic joint (SYNOP).

Normal Volume
1 mL fluid
Minimum Volume
1 mL fluid
Additional Information

Test includes CRP, Hemoglobin, and Alpha Defensin. Test sent to Citrano Diagnostic Labs.

CPT Code
86140, 84311, 83516
Fee Code
AA252, AA253, AA254
NY State Approved