Test Overview
Test Methodology

Immunoassay

Test Usage

Synovasure® Alpha Defensin test results are intended to be used in conjunction with other clinical and diagnostic findings to aid a patient’s diagnosis. Synovasure® Alpha Defensin is intended to determine whether there is an infection present in the synovial fluid of a joint. Results do not identify a specific type of infection or establish the origin or severity of an infection. Results provide a physician with a specific positive or negative indication for the presence of the alpha defensin biomarker that is released into the synovial fluid by the patient’s cells while fighting an infection.

Reference Range *

Alpha Defensin Negative
CRP < 3 mg/L for the PJI test and < 7.5 mg/L in the NSA test
Hemoglobin < 20 g/L

Test Details
Days Set Up
Monday - Friday
Analytic Time

2 - 5 days

Soft Order Code
SYNOS or SYNOP
MiChart Code
SYNOS/SYNOP
Synonyms
  • Alpha Defensins, Synovial Fluid
Laboratory
Sendout
Reference Laboratory
Citrano Diagnostic Labs
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect aspirate from affected joint. Aspirate must must put into a plain red top tube. Send to Specimen Processing at ambient temperature. Please indicate if fluid was collected from a non-replacement joint (native) (SYNOS) or from a prosthetic joint (SYNOP).

Red Top Tube
Normal Volume
1 mL fluid
Minimum Volume
1 mL fluid
Additional Information

Test includes CRP, Hemoglobin, and Alpha Defensin. Test sent to Citrano Diagnostic Labs.

Billing
CPT Code
86140, 84311, 83516
Fee Code
AA252, AA253, AA254
NY State Approved
No