Days Set Up
Monday - Friday
Analytic Time

2 - 5 days

MiChart Code
Soft Order Code

Test Updated:


Alpha Defensins, Synovial Fluid

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Test Overview

Test Methodology


Test Usage

Synovasure® Alpha Defensin test results are intended to be used in conjunction with other clinical and diagnostic findings to aid a patient’s diagnosis. Synovasure® Alpha Defensin is intended to determine whether there is an infection present in the synovial fluid of a joint. Results do not identify a specific type of infection or establish the origin or severity of an infection. Results provide a physician with a specific positive or negative indication for the presence of the alpha defensin biomarker that is released into the synovial fluid by the patient’s cells while fighting an infection.

Reference Range

Alpha Defensin Negative
CRP < 3 mg/L for the PJI test and < 7.5 mg/L in the NSA test
Hemoglobin < 20 g/L

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Collect aspirate from affected joint. Aspirate must must put into a plain red top tube. Send to Specimen Processing at ambient temperature. Please indicate if fluid was collected from a non-replacement joint (native) (SYNOS) or from a prosthetic joint (SYNOP).

Red Top Tube
Normal Volume
1 mL fluid
Minimum Volume
1 mL fluid

Billing Information

CPT Code
86140, 84311, 83516
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.