Update Type: Test Methodology Changed
Test Updated: 07/05/2023
Test Overview
Test Methodology

Microsphere Photometry

Test Usage

Assessing the IgG antibody response to active immunization with nonconjugated, 23-valent vaccines. Assessing the IgG antibody response to active immunization with conjugated, 13-valent vaccines. Determining the ability of an individual to produce an antibody response to polysaccharide antigen(s), as part of an evaluation for humoral or combined immunodeficiencies.

Reference Range *

Result reported in mcg/mL; results greater than the reference value are consistent with a positive immune response.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

The humoral immune response to S. pneumoniae is age dependent, and the database of IgG antibody concentrations to different serotypes is incomplete. The minimum concentration of IgG antibody necessary to ensure protection against invasive disease has not been determined for any serotype. Serotype specific antibodies may persist for up to 10 years following immunization or infection.

Test Details
Days Set Up
Monday - Friday
Analytic Time

4 - 7 days

Soft Order Code
MiChart Code
Strep Pneumonia IgG Antiby Panel (23)
  • Anti-Pneumococcal Antibodies
  • Pneumococcal Antibody Titer, IgG
  • Pneumococcal IgG Vaccine Response, ELISA
  • Pneumo-Vax Response
  • S. pneumoniae IgG Antibody
  • S. pneumoniae IgG Ab, 7 Seroty
  • S. pneumoniae IgG Ab,23 seroty
  • PN23
  • PN7
Reference Laboratory
Mayo PN23M
Special Testing
Specimen Requirements
Collection Instructions

Collect blood in a red top or SST tube. Centrifuge, aliquot serum into plastic vial and refrigerate. Pre- and post-vaccination samples submitted at the same time are recommended. Post-vaccination samples should be collected 4-6 weeks from the date of vaccination.

Normal Volume
0.5 mL serum
Minimum Volume
0.4 mL serum
Additional Information

Includes serotypes 1(1), 2(2), 3(3), 4(4), 5(5), 8(8), 9N(9), 12F(12), 14(14), 17F(17), 19F(19), 20(20), 22F(22), 23F(23), 6B(26), 10A(34), 11A(43), 7F(51), 15B(54), 18C(56), 19A(57), 9V(68), and 33F(70). Testing should be performed with pre- and post- vaccination sera. Test sent to Mayo Medical Laboratories.

CPT Code
86317 x23
Fee Code