Collect specimen from anorectum. Insert swab into aerobic transport tube and bend the swab at the breakpoint to break the shaft. Refrigerate and send within 48 hours of collection. Specimen should be sent for culture before antimicrobial therapy is started. If performing a rapid strep screen at the point of care, after collection insert the swab into the Eswab liquid, swish to mix well and then remove the swab to use for the onsite rapid test. If the rapid test is negative the remaining liquid in the Eswab transport tube may be sent for culture; do not place the swab back into the liquid after performing the rapid test.