Update Type: Test Code Change
Test Updated: 11/06/2024
Test Overview
Test Methodology

Direct RIA

Test Usage

Somatostatin is a cyclic peptide originally isolated from sheep hypothalami and shown to inhibit the release of Growth Hormone. Somatostatin is present primarily in three main forms: a 14 amino acid peptide, a 28 amino acid peptide ("Big" Somatostatin), and a 12,000 molecular weight ProSomatostatin. This assay measures only the 14 amino acid form of Somatostatin. All three forms of Somatostatin have similar biological properties and overall potencies. Somatostatin is a physiological regulator of Islet Cell and gastrointestinal functions, and is a suppressor of many pituitary hormones including Growth Hormone, Prolactin, and Thyrotropin (TSH). Somatostatin levels are often elevated in diabetics, but the levels return to normal upon correction of the hormonal and metabolic deficiencies present. In many cases of APUDomas including VIPoma, Insulinoma, Glucagonoma, and Gastrinoma, elevated levels of Somatostatin are found.

Reference Range *

< 25 pg/mL

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Friday
Analytic Time

9 - 11 days

Soft Order Code
FSOM1
MiChart Code
Somatostatin
Synonyms
  • Somatotropin Release Inhibiting Factor
Laboratory
Sendout
Reference Laboratory
Mayo FSOM1 (Interscience)
Section
Special Testing
Specimen Requirements
Collection

Either EDTA lavender top tube, or GI Preservative tube are acceptable.

Collection Instructions

Collect specimen in EDTA lav top tube. For baseline determination collect specimen following an overnight (10-12 hour) fast. Following collection, centrifuge, aliquot plasma into a plastic vial, and freeze. If possible, discontinue insulin medication prior to collection.

Special Handling

Fasting specimen. EDTA lavender top tube is now preferred, but special "G.I. Preservative" tube is acceptable. (Stored in the refrigerator in Sendouts)

Alternate Specimen
G.I. Preservative tube, provided by Mayo and stored in Sendouts refrigerator
Normal Volume
1.5 mL plasma
Minimum Volume
1 mL plasma
Storage Temperature
STRICT frozen
Rejection Criteria
Specimen not stored frozen
Additional Information

Test sent to Mayo Medical Laboratories; performed by Interscience Institute.

Billing
CPT Code
84307
Fee Code
19606
NY State Approved
No