5 days
Test Updated:
HLA Antibody Screening
HLA Typing Class I and II
Percent Reactive Antibody (PRA)
New Patient, Solid Organ Tx
SONP
HLA REPORT
HLLR
HLA Antibody Specificity Class II
HLA Class II Low Resolution
HLA Class I Low Resolution
TTYPE
TISSUE TYPING
HLA Antibody Specificity Class I
HLAS
Looking to order a test?
We’ve provided helpful links to make ordering easy.
Find a RequisitionAll specimens should be accompanied by a requisition.
Submitting SpecimensLearn about how to properly label and where to ship specimens.
Order Kits and SuppliesMLabs provides all the supplies necessary for the collection of specimens.
Test FAQVisit our provider FAQ and learn about common questions to ordering tests.
Test Overview
Molecular Typing (SSO) and Solid Phase Assay
At the UMHS Histocompatibility Laboratory potential recipients are typed for HLA-A, B, C, DRB1,3,4,5, DQB1, DQA1 loci by medium/low resolution SSO molecular methods. Each recipient is screened to detect preformed anti-HLA antibodies. Patients may develop these antibodies in case of previous sensitization events like transfusion, pregnancies or previous transplant. When these antibodies are detected the Panel Reactive Antibody (PRA%) value is assigned and the anti-HLA antibody specificity is defined by Solid Phase Single Antigen assays. PRA% values are updated with a new sample every 3 months. For patients listed for transplant with a deceased donor the Histocompatibility Laboratory will updated PRA% and the Unacceptable Antigens list in the UNOS database every 3 months. Every month a fresh serum sample is mailed to the Organ Procurement Organization (OPO). This serum sample and the historic higher PRA% sample (peak) will be used for Flow Cytometric Crossmatch with matched deceased donors.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.