Evaluation of possible severe combined immunodeficiency. Testing is performed only on infants identified by State of Michigan TREC study as potential SCIDS patients. A full lymphoid cell panel is run, including B and T cell, T subsets, T-memory and naive subsets, and natural killer cell quantitation. Markers include:
Calculated CD4:CD8 ratio (T4:T8 ratio)
[link text="SCIDS reference range.docx" href="/static/apps/handbook/Tables/SCIDS reference range.docx"]
[bold]*Pediatric Reference Ranges from Journal of Allergy and Clinical Immunology, vol. 112, No. 5, 11/2003 and studies performed at Michigan Medicine Flow Cytometry Laboratory. Absolute ranges are calculated utilizing absolute lymphocyte count ranges for the same age groups provided by the hematology laboratory.[/bold]
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Requires an adequate number of viable cells for analysis. Improper collection or transport may result in decreased cell viability and cancellation of testing.Specimen collection should be arranged so that specimen will be received Monday-Friday, 8:00 am - 4:30 pm. Refrigeration of specimens may result in the deterioration of surface markers.
Absolute counts CANNOT be reported without accompanying CBCD.
Days Test Performed
Monday - Friday, 8:00am - 4:30pm; Saturday, 8:00am - 12:00noon
24 - 48 hours
Soft Order Code
SCID panel: T,B,NK Quant (CD3,4,8,19,16/56) with 45RA/RO. Restricted to pat
SCID (Severe Combined Immunodeficiency Disorder)
Immunodeficiencies Profile, SCID
SCID Panel Shadow
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Offsite Collection Instructions
Testing performed only for University of Michigan registered patients.
Green top lithium tubes are not acceptable.
Whole blood: 3 ml added to each tube
Whole blood: 1 ml added to each tube tube