Test Overview

Test Usage

Evaluation of possible severe combined immunodeficiency. Testing is performed only on infants identified by State of Michigan TREC study as potential SCIDS patients. A full lymphoid cell panel is run, including B and T cell, T subsets, T-memory and naive subsets, and natural killer cell quantitation. Markers include:
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CD3+
CD3+CD4+
CD3+CD8+
CD3-CD16/56+
CD19+
CD3+CD4+CD45RA+
CD3+CD4+CD45RO+
CD3+CD8+CD45RA+
CD3+CD8+CD45RO+
Calculated CD4:CD8 ratio (T4:T8 ratio)
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Reference Range*

[link text="SCIDS reference range.docx" href="/static/apps/handbook/Tables/SCIDS reference range.docx"]
[bold]*Pediatric Reference Ranges from Journal of Allergy and Clinical Immunology, vol. 112, No. 5, 11/2003 and studies performed at Michigan Medicine Flow Cytometry Laboratory. Absolute ranges are calculated utilizing absolute lymphocyte count ranges for the same age groups provided by the hematology laboratory.[/bold]

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Requires an adequate number of viable cells for analysis. Improper collection or transport may result in decreased cell viability and cancellation of testing.Specimen collection should be arranged so that specimen will be received Monday-Friday, 8:00 am - 4:30 pm. Refrigeration of specimens may result in the deterioration of surface markers.
[list]
Absolute counts CANNOT be reported without accompanying CBCD.
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Test Details

Days Test Performed

Monday - Friday, 8:00am - 4:30pm; Saturday, 8:00am - 12:00noon

Analytic Time

24 - 48 hours

Soft Order Code

SCIDS

MiChart Code

SCID panel: T,B,NK Quant (CD3,4,8,19,16/56) with 45RA/RO. Restricted to pat

Synonyms

Synonyms

SCID (Severe Combined Immunodeficiency Disorder)
Immunodeficiencies Profile, SCID
Newborn Screen
SCIDS PANEL
SCIDS
SCIDT
SCID Panel Shadow

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Laboratory

Flow Cytometry

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Specimen Requirements

Offsite Collection Instructions

Testing performed only for University of Michigan registered patients.

Rejection Criteria

Green top lithium tubes are not acceptable.

Normal Volume

Whole blood: 3 ml added to each tube

Minimum Volume

Whole blood: 1 ml added to each tube tube

Billing Information

Fee Codes


CPT Code

86355, 86357, 86359, 86360, 86356 x4

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