Test Overview
Test Methodology

Liquid Chromatography Tandem Mass Spectrometry

Test Usage

In conjunction or as an alternative to 5-HIAA or serum chromogranin A measurements as a first line test in the diagnosis of carcinoid syndrome.

Reference Range *

<=230 ng/mL

Test Limitations

Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine.

Test Details
Days Set Up
Monday, Wednesday, Friday
Analytic Time

4 - 9 days

Soft Order Code
SEROS
MiChart Code
Serotonin
Synonyms
  • 5-Hydroxytryptamine
  • Hydroxytryptamine, 5-
  • SEROTS
  • SEROTONIN, SERUM
  • SEROS
Laboratory
Sendout
Reference Laboratory
Mayo SER (84395)
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge as soon as blood has clotted, aliquot serum into a plastic vial within 30 minutes of collection and refrigerate.

Special Handling

Deliver to lab within 15 minutes or aliquot within 30 minutes. Spin as soon as blood has clotted.

Yellow Top Tube
Normal Volume
2.5 mL serum
Minimum Volume
1.1 mL serum
Additional Information

The preferred sample for measurement of serotonin includes all or most of the platelets (i.e., whole blood) or serum from completely clotted specimens. Serotonin- or tryptophan-rich foods (avocados, bananas, plums, walnuts, pineapple, eggplant, plantain, tomatoes, hickory nuts, kiwi, dates, grapefruit, cantaloupe, and honeydew melon) do not contribute significantly to serum or blood serotonin measurements, but can elevate platelet-poor plasma serotonin, urinary serotonin, and urinary 5-HIAA levels markedly (up to 10-fold). Test sent to Mayo Medical Laboratories.

Billing
CPT Code
84260
Fee Code
32131
NY State Approved
No