Test Overview

Test Methodology

Multiplex Flow Immunoassay

Test Usage

Support the diagnosis of measles or SSPE (sub-sclerosing pan ecephalitis) infection. The presence of IgG antibody generally indicates past exposure and immunity. The presence of IgM antibody or a fourfold or greater rise in IgG antibodies in paired sera indicates recent infection. Single IgG levels are not useful for supporting the diagnosis of an acute infection. Elevated levels in neonates should be followed up with studies to rule out the presence of maternal antibodies by demonstrating the absence of an IgM response.

Reference Range*

NEGATIVE: No Rubeola IgG antibody detected; POSITIVE: Rubeola IgG Antibody detected, indicating previous exposure and immunity to Rubeola virus.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

A single elevated serum sample cannot be considered diagnostic of SSPE (sub-sclerosing pan ecephalitis). While cases of SSPE may have responses of 10 - 100X those generally seen, the best indicator is the detection of elevated levels of IgG specific for rubeola antigens in CSF as compared to those found in serum, suggesting local IgG production in CSF. In persons with normal immune systems, postinfectious encephalitis has no accompanying enhanced antibody response. Increasing titers of serum antibodies to rubeola virus, as well as other viruses (rubella), have been associated with active chronic hepatitis, systemic lupus erythematosus and infectious mononucleosis. The performance characteristics of this test have not been established for CSF, neonates, infants or cord blood. This is a qualitative test; quantitation for comparison of acute and convalescent sera has not been validated by the manufacturer of the current test system. Result values from different methodologies or from different institutions cannot be compared. Timing of specimen collection for paired sera is critical. In some patients, antibody may rise to significant levels and fall again to lower or undetectable levels within a month. Other patients may not develop significant antibody levels.

Test Details

Days Test Performed

Monday - Friday

Analytic Time

24 hours

Soft Order Code


MiChart Code

Rubeola Antibody IgG



Measles Antibody IgG
Viral Antibody: Rubeola IgG
MMR Vaccine Response
Rubeola IgG Antibody

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Chemical Pathology

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate up to 7 days. Post-vaccination samples should be collected 4-6 weeks from the date of vaccination.


Yellow Top Tube

Normal Volume

0.5 mL serum

Minimum Volume

0.2 mL serum

Additional Information

Titers will not be reported. Numerical EIA results for single serum specimens do not reflect the magnitude of the measured result above the cut off and are not indicative of the total amount of antibody present. The magnitude of the reported IgG level cannot be correlated to an endpoint titer. Screening for Rubeola antibodies by serological methods will establish the immune status of individuals with regard to their resistance or susceptibility to measles infection. It is always helpful to support serological tests with virus isolation from respiratory specimens early in the disease before the rash, then from the cutaneous lesions, and later from the urine.

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