Test Overview

Test Methodology

Fluorescence In Situ Hybridization (FISH)

Test Usage

This test detects rearrangements involving the RET gene region (10q11) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using break-apart probes (Abbott Molecular) to qualitatively assess for the presence of RET translocations that occur in non-small cell lung cancer (NSCLC) and thyroid carcinomas. Lung cancer patients with tumors harboring RET rearrangements may benefit from kinase inhibitor therapy.

Test Limitations

This test will detect rearrangements involving RET but will not identify the translocation partner. This test may not detect RET rearrangements in some cases due to the intrachromosomal proximity of some fusion partners.

Test Details

Days Test Performed

Monday - Thursday

Analytic Time

3 - 10 days

Soft Order Code

MRET

MiChart Code

RET (10q11) Rearrangement by FISH

Synonyms

Synonyms

MRET

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Laboratory

Molecular Diagnostics

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Specimen Requirements

Offsite Collection Instructions

A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.

Normal Volume

Formalin-fixed, paraffin-embedded tissue

Additional Information

By ordering this test the clinician acknowledges that informed consent has been obtained from the patient as required by applicable state or federal laws and the ordering clinician has authorization from the patient permitting MLabs to report the test results to the ordering clinician. Test includes pathologist interpretation of results billed as a separate additional charge. This test is not available without interpretation.

Billing Information

Fee Codes


CPT Code

88377-TC

New York State Approved

No

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