Test Overview
Test Methodology


Test Usage

Evaluate the role of renin in the differential diagnosis of hypertension.

Reference Range *

Upright: <= 40 years, 4.0 - 44.0 pg/mL; > 40 years, 4.0 - 60 pg/mL
Supine (more than 30 minutes): <= 40 years; 3.0 - 30 pg/mL; > 40 years, 3.0 - 42.0 pg/mL. Contact the MLabs Client Services Center for interpretation by the Hypertension Unit (936-4790).

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Tuesday, Friday
Analytic Time

8 hours

Soft Order Code
MiChart Code
Renin, Plasma Mass
Chemical Pathology
Special Chemistry
Specimen Requirements
Collection Instructions

Collect specimen in a lavender top tube (EDTA). Centrifuge, aliquot plasma into a plastic vial, and freeze within 2 hour. Do not refrigerate the sample.

Normal Volume
1 mL plasma
Minimum Volume
0.50 mL plasma
Rejection Criteria
Specimen not drawn in lavender top tube, specimen not frozen, specimen refrigerated, clotted sample.
Additional Information

When screening for primary hyperaldosteronism, both renin and aldosterone are best interpreted together.

1) If plasma renin mass is less than 8 pg/mL and:
· aldosterone of less than 10 ng/dL: Unlikely primary aldosteronism
· aldosterone of 10 to 20 ng/dL: Possible primary aldosteronism
· aldosterone of greater than 20 ng/dL: Suggestive of primary aldosteronism
2) If plasma renin mass is greater than or equal to 8 pg/mL and:
· the ratio of aldosterone to plasma renin mass is greater than 2.6 (ng/dL:pg/mL), findings are suggestive of primary aldosteronism

Multiple factors including medications, sodium status, and other causes may influence these values and could potentially lead to false-positive or false-negative results; these factors should be considered in interpretation as noted in Endocrine Society guidelines [Funder JW et al. J Clin Endocrinol Metab. 2016, 101(5):1889-1916].

Screening BPA Interpretation Guide

CPT Code
Fee Code