Test Overview
Chemiluminescent Immunometric Assay
Assessment of prenatal risk for Down Syndrome (Trisomy 21), neural tube defects (NTD), and Edwards Syndrome (Trisomy 18).
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Specimen must be from a patient with a maternal gestation of between 15 weeks 0 days and 22 weeks 6 days. Specimens with a maternal gestation after this time period will automatically be forwarded to Michigan State University for testing. MLabs recommends that specimens with a maternal gestation of less than 15 weeks be re-collected at a later time period.
Test Details
2 - 3 days
- Quad Screen Maternal Serum
- AFP, Quad Test Profile
- Alpha Fetoprotein, Quad Test Profile
- Quadruple Test
- Triple Test Replacement Assay
- Edwards Syndrome (Trisomy 18) Risk
- Neural tube defects (NTD) Risk
- Prenatal risk for fetal congenital abnormalities
- Down Syndrome (Trisomy 21) Risk
Specimen Requirements
Collect specimen in a red top tube from a patient with a maternal gestation of between 15 weeks 0 days and 22 weeks 6 days. Centrifuge, aliquot serum into a plastic vial within 2 hours of collection and refrigerate. (Frozen is also acceptable). Please provide a completed QUAD/AFP Requisition available online at https://mlabs.umich.edu/media/170 or the following information: gestational age (weeks and days on first ultrasound date >6 weeks 0 days; if ultrasound information is not available record first days of last menstrual period), maternal weight, maternal date of birth, insulin-dependent diabetes status prior to pregnancy, multiple gestation (single, twin, triplets), race, and previous history of Down syndrome or neural tube defect (NTD) pregnancy for the patient.
1 mL serum
0.6 mL serum
Additional Information
Test includes Alpha Fetoprotein (AFP), Beta Subunit of Human Chorionic Gonadotropin (hCG), Unconjugated Estriol (UE3), and Inhibin A. If there is a family history of neural tube defects, consultation with a genetic counselor to more accurately assess increased risk for neural tube defects is recommended. Test sent to Warde Medical Laboratory.