Test Overview
Electrochemiluminescent Assay
As part of the diagnostic workup of suspected insulinoma; as part of the diagnostic workup of patients with suspected prohormone convertases1/3 deficiency; as part of the diagnostic workup of patients with suspected proinsulin mutations.
3.6 - 22 pmol/L
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
To avoid misdiagnoses, all proinsulin measurements used in the diagnostic workup of patients with hypoglycemia must be interpreted in the context of coexisting illnesses, blood glucose concentration at the time of sampling, and other tests, namely, insulin, c-peptide, beta-hydroxybutyrate measurements, and a sulfonylurea drug screen. Patients with chronic renal failure and type II diabetes mellitus can have increased proinsulin, c-peptide, and insulin values, but usually without suppressed (<45 mg/dL) blood glucose.
Test Details
2 - 7 days
Specimen Requirements
Collect specimen in a chilled lavender top tube from a fasting patient. Chill the whole blood on ice for at least 10 minutes, spin down in a refrigerated centrifuge, aliquot plasma into a plastic vial and freeze. If a refrigerated centrifuge is not available, the patient should have the specimen collected at a UM Medical Center Center Blood Drawing station (on-site).
If refrigerated centrifuge is not available, the patient should have the specimen collected at a UM Medical Center Center Blood Drawing station (on-site).
Fasting specimen. Collect in prechilled tube and place on ice immediately. Must arrive in lab, (or to Specimen Processing), to be spun down in a refrigerated centrifuge, aliquotted, and frozen within 10 minutes of collection.
Additional Information
Test sent to Mayo Medical Laboratories.