Used to identify and quantitate a plasminogen defect or deficiency in those patients subject to recurrent venous thrombosis or pulmonary emboli.
81 - 151%
Reduced plasminogen levels occur in patients receiving thrombolytic therapy.
- PLASMINOGEN ACTIVITY
Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 3 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.
Decreased levels are seen in DIC, hepatitis, sepsis, hepatitis, leukemia and pancreatitis. It is increased in the 2nd and 3rd trimester of pregnancy. Plasminogen is temporarily depleted during thrombolytic therapy, especially when streptokinase is used. Levels are increased during pregnancy. Newborns have about 50% of adult levels.