Test Overview
Test Methodology


Test Usage

Used to identify and quantitate a plasminogen defect or deficiency in those patients subject to recurrent venous thrombosis or pulmonary emboli.

Reference Range *

81 - 151%

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Reduced plasminogen levels occur in patients receiving thrombolytic therapy.

Test Details
Days Set Up
Analytic Time

1 hour

Soft Order Code
MiChart Code
Plasminogen Activity
Specimen Requirements
Collection Instructions

Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 3 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic vial, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.

Normal Volume
Full 2.7mL tube or 1mL plasma aliquot
Minimum Volume
Full 1.8mL tube or 1mL plasma aliquot
Storage Temperature
Room temperature for whole blood or frozen aliquot of citrated plasma
Rejection Criteria
Specimens will be rejected if not properly filled, clotted, grossly hemolyzed, or contaminated with heparin.
Additional Information

Decreased levels are seen in DIC, hepatitis, sepsis, hepatitis, leukemia and pancreatitis. It is increased in the 2nd and 3rd trimester of pregnancy. Plasminogen is temporarily depleted during thrombolytic therapy, especially when streptokinase is used. Levels are increased during pregnancy. Newborns have about 50% of adult levels.

CPT Code
Fee Code