Test Overview
Test Methodology

Enzyme Linked Immunosorbent Assay (ELISA)

Test Usage

Primary membranous nephropathy is an autoimmune disease which demonstrates autoantibodies to the M-type phospholipase A2 receptor (PLA2R) in up to 70% of patients. Autoantibodies to PLA2R may be useful in distinguishing primary membranous nephropathy from secondary membranous nephropathy and other forms of glomerulonephritis. As such, testing for anti-PLA2R antibodies may be useful in patients with idiopathic nephrotic syndrome. In PLA2R antibody-positive patients, quantitative changes in the anti-PLA2R value generally precedes a change in clinical status with respect to clinical remission, relapse, or risk assessment after kidney transplantation.

Reference Range *

Negative: <14 RU/mL
Borderline: 14 - 19 RU/mL
Positive: >19 RU/mL

Test Details
Days Set Up
One day weekly; Wednesday
Soft Order Code
PLA2R
Laboratory
Chemical Pathology
Section
Special Chemistry
Specimen Requirements
Collection

Collect specimen in an SST tube. Centrifuge, aliquot in plastic tubes, freeze.

Normal Volume
0.5 mL serum
Minimum Volume
0.25 mL serum
Storage Temperature
Freeze at -25 °C. Add-ons may be done to refrigerated samples up to 48 hours old.
Billing
CPT Code
83520
Fee Code
KA053
LOINC
73737-9
NY State Approved
No