Update Type: Test Code Change
Test Updated: 12/23/2025
Test Overview
Test Methodology

Liquid chromatography Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Monitoring therapeutic efficacy/compliance in serum specimens of patients who are prescribed oxycodone and/or oxymorphone.

Reference Range *

Oxycodone: 10-100 ng/mL; Noroxycodone: Metabolite of oxycodone; Oxymorphone Metabolite of oxycodone: 1.0-8.0 ng/mL when used as sole therapy; Noroxymorphone: Metabolite of oxymorphone

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Wednesday
Analytic Time

2 - 4 days

Soft Order Code
MMLR
MiChart Code
Oxycodone Level
Synonyms
  • OxyContin, Serum or Plasma
  • Percocet, Serum or Plasma
  • Percodan, Serum or Plasma
  • Roxicodone, Serum or Plasma
Laboratory
Sendout
Reference Laboratory
Mayo OXYDS
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top tube, NO SST. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Normal Volume

1 mL serum

Minimum Volume

1 mL serum

Storage Temperature
Refrigerated preferred, frozen acceptable
Additional Information

Test performed by Mayo Clinic Laboratories.

Billing
CPT Code
G0480/80365
Fee Code
32155
NY State Approved
No