Update Type: Test Code Change
Test Updated: 12/23/2025
Test Overview
Test Methodology

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Monitoring therapeutic efficacy/compliance in serum specimens of patients who are prescribed oxycodone and/or oxymorphone.

Reference Range *

Therapeutic range/Metabolite information (as applicable):
Oxycodone: 10-100 ng/mL
Noroxycodone: Metabolite of oxycodone
Oxymorphone: Metabolite of oxycodone; 1.0-8.0 ng/mL when used as sole therapy
Noroxymorphone: Metabolite of oxymorphone

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Wednesday
Analytic Time

2 - 4 days

Soft Order Code
MMLR
MiChart Code
Oxycodone Level
Synonyms
  • OxyContin, Serum or Plasma
  • Percocet, Serum or Plasma
  • Percodan, Serum or Plasma
  • Roxicodone, Serum or Plasma
Laboratory
Sendout
Reference Laboratory
Mayo OXYDS
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top tube. Centrifuge, aliquot serum into a plastic vial and refrigerate. EDTA (lavender top) or heparinized (green top) plasma is also acceptable.

Normal Volume

5 mL serum

Minimum Volume

0.5 mL serum

Additional Information

Test sent to Mayo Clinic Laboratories.

Billing
CPT Code
G0480/80365
Fee Code
32155
NY State Approved
No