Test Overview
Test Methodology

Osmotic Lysis

Test Usage

Suspected hereditary spherocytic hemolytic anemia.

Reference Range *

> or =12 months: 0.50 g/dL NaCl (unincubated): 3-53% hemolysis; 0.60 g/dL NaCl (incubated): 14-74% hemolysis; 0.65 g/dL NaCl (incubated): 4-40% hemolysis; 0.75 g/dL NaCl (incubated): 1-11% hemolysis. Reference values have not been established for patients who are <12 months of age.

Test Details
Days Set Up
Monday - Saturday
Analytic Time

2 - 5 days

Soft Order Code
OFRAG
MiChart Code
Osmotic Fragility, RBC (Sendout)
Synonyms
  • RBC Osmotic Fragility
  • FRAG
  • OFRAG
  • Osmotic Fragility, RBC
Laboratory
Sendout
Reference Laboratory
Mayo FRAG (9064)
Section
Special Testing
Specimen Requirements
Collection

Specimens must be received by performing laboratory within 72 hours of collection. Collect specimen in a lavender top tube. Also collect a normal control specimen in a lavender top tube from an unrelated, non-smoking individual at the same time that the patient is drawn (label "normal control"). Refrigerate both intact specimens; do not transfer blood to other tubes.

Normal Volume
5 mL whole blood
Minimum Volume
2 mL whole blood
Additional Information

Test sent to Mayo Medical Laboratories.

Billing
CPT Code
85557
Fee Code
34906
NY State Approved
No