Test Overview
Test Methodology

Enzyme-linked immunosorbent assay (ELISA)

Test Usage

Anti-NXP-2 antibodies are present in 1.6-30% of adult DM and 18-25% of JDM. In JDM they are associated with cutaneous calcinosis cutis. In adult DM they are significantly associated with the presence of cancer (cancer was found in 13.6% of Anti-NXP-2 positive DM patients). Anti-MDA5 antibodies are present in 7-35% of adult DM. Features consist of absent or mild muscle symptoms (CADM); associated with rapidly progressive ILD; specific mucocutaneous features of skin ulcerations and papules; higher risk of oral ulcerations and arthritis.

Reference Range *

Negative: <20 units, Weak positive: 20-39 units, Moderate positive: 40-80 units, Strong positive: >80 units

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Analytic Time

8 - 11 days

Soft Order Code
LNXP2
MiChart Code
Anti-NXP2
Synonyms
  • Anti-NXP2
  • NXP-2 (P140)
Laboratory
Sendout
Reference Laboratory
Labcorp Esoterix 520004
Section
Special Testing
Specimen Requirements
Collection

Collect specimen in an SST tube. Centrifuge within an hour of collection, aliquot serum into a plastic vial and refrigerate.

Normal Volume

1 mL serum

Minimum Volume

0.5 mL serum

Storage Temperature
Refrigerated preferred, frozen acceptable
Additional Information

Test sent to Labcorp-Esoterix (RDL Reference Laboratories).

Billing
CPT Code
83516
Fee Code
AA933
NY State Approved
No