3 – 10 days
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Fluorescence In Situ Hybridization (FISH)
NR4A3 encodes an orphan nuclear receptor. Rearrangements of NR4A3 occur in more than 80% of extraskeletal myxoid chondrosarcoma (EMC) as well as in salivary acinic cell carcinoma (AciCC), driving tumorigenesis. With EMC, NR4A3 rearrangements fuse the 3’ end of NR4A3, including its DNA binding domain, to a variety of 5’ oncogenic transcription activator fusion partners. With AciCC, NR4A3 rearrangement translocates highly active chromatin regions to the upstream region of NR4A3. The detection of NR4A3 rearrangements can be useful in diagnosing EMC and AciCC – including uncommon histologic variants – and in distinguishing these neoplasms from other myxoid neoplasms and salivary gland tumors, respectively.
Interpretive report provided.
*Reference ranges may change over time. Please refer to the original patient report when evaluating results.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
A formalin-fixed, paraffin-embedded tissue block (containing sufficient neoplastic cells) is preferred. Unstained slides (3 slides cut at 4-microns) with associated H&E-stained slide are also acceptable. Decalcified tissue or tissues with other fixatives will be accepted and the assay attempted; however, these specimens may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.