Test Overview
Test Methodology

Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Monitor therapeutic drug levels; monitor patient compliance; evaluate nortriptyline toxicity

Reference Range *

Therapeutic: 70 - 170 ng/mL. Therapeutic ranges are for specimens drawn at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Tuesday, Thursday, Sunday
Analytic Time

3 - 5 days

Soft Order Code
NOTRP
MiChart Code
Nortriptyline Level
Synonyms
  • Aventyl
  • Pamelor
  • Tricyclics, Nortriptyline
Laboratory
Sendout
Reference Laboratory
Mayo NOTRP
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect blood in a red top tube immediately before next scheduled dose (minimum 12 hours after last dose); do not use SST tube. Centrifuge, aliquot serum or plasma into plastic vial within 2 hours of collection, and refrigerate.

Alternate Specimen

In house test NORT down/discontinued 7/8/2022, send to Mayo NOTRP.

Normal Volume

1 mL serum

Minimum Volume

0.25 mL serum

Rejection Criteria
SST or PST tube not acceptable.
Additional Information

Test sent to Mayo Clinic Laboratories.

Billing
CPT Code
80335
Fee Code
AB138
LOINC
3872-9
NY State Approved
No