Days Set Up
Monday - Friday
Analytic Time

28 days

MiChart Code
Noonan Syndrome Tiered Testing
Soft Order Code

Test Updated:


Noonan Sequencing Panel
PTPN11 (3 EX)+SOS1 (4 EX) SEQ
PTPN11(remaining ex)seq Shadow
KRAS(5ex)+SOS1(19ex)seq Shadow
KRAS (5 EX)+SOS1 (19 EX) SEQ
PTPN11 Mutation Analysis
SOS1 Mutation Analysis
KRAS2 Mutation Analysis
RAF1 Mutation Analysis
Noonan Syndrome Sequencing Panel

Looking to order a test?

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

Visit our provider FAQ and learn about common questions to ordering tests.

Test Overview

Test Methodology

The coding exons and associated, adjacent consensus splice sites of the PTPN11, SOS1, and KRAS2 genes plus 3 coding exons of the RAF1 genes are amplified using specific primers, and bidirectionally sequenced using a fluorescent method.

Test Usage

To detect the presence of PTPN11, SOS1, KRAS2, and RAF1 mutations in patients with Noonan syndrome and for carrier testing in families with a known pathogenic mutation for Noonan syndrome.

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Collect specimen in a lavender top tube. Send intact specimen within 24 hours if stored at room temperature or within 5 days if stored refrigerated. Include the patient's family history, pedigree, and ethnicity on the test requisition. Obtaining informed consent from the patient prior to genetic testing is strongly recommended. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained from the MMGL Molecular Genetics Laboratory by contacting the MLabs Client Services Center at 800-862-7284 or online at….

Lavender Top Tube
Normal Volume
5 - 10 mL EDTA whole blood
Minimum Volume
2 mL EDTA whole blood

Billing Information

CPT Code
Tier I: 81405; Tier II: 81406; Tier III: 81406
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.